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Synopsis: 111 patients with Kellgren-Lawrence grade I-IV symptomatic knee osteoarthritis were randomized to three weekly intraarticular injections of either leukocyte-poor platelet-rich plasma (LP-PRP) or hyaluronic acid.Patients were assessed for pain and function over a 52-week follow-up.The primary outcome measure, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score, demonstrated no significant difference between groups at any time point.In contrast, pain scores on a visual analog scale (VAS) demonstrated significantly lower pain in the LP-PRP group compared to the HA group at 24- and 52-week follow-up. Similarly International Knee... Read More »
Author verified Level 2 RCT
6%
Synopsis: 18 randomized controlled trials were included in this network meta-analysis to evaluate the effect of platelet-rich plasma injections in the management of tendinopathies and if outcomes are affected by the type of preparation.The results from this study indicate that platelet-rich plasma is an effective treatment for tendinopathies and that leukocyte-rich platelet-rich plasma preparations appear to have the greatest effect. However, further trials... Read More »
Author verified Level 2 Meta Analysis
4%
Synopsis: 14 randomized controlled trials were included in this systematic review and meta-analysis to evaluate the use of corticosteroid injections in the management of rotator cuff tendinosis in comparison to a placebo.The primary outcome of interest for this meta-analysis was pain assessed at 3 months (12 weeks).A subgroup analysis was also performed to compare the efficacy of single vs multiple injections.The results of this study indicated that corticosteroid injections provided greater reductions in pain at 4 and 8 weeks compared to placebo, however, these differences were small and not clinically relevant.There were no differences observed between groups at 12 weeks.Additionally, there were no differences observed between single and multiple injections of a corticosteroid. Read More »
Author verified Meta Analysis
4%
Synopsis: 151 patients with shoulder stiffness were randomized to an intraarticular injection of either 40mg or 20mg triamcinolone acetonide (TA).The purpose of this study was to evaluate if high-dose TA demonstrated a significantly greater post-injection range of motion compared to low-dose TA.Average follow-up length was 17.6 months in the 40mg group and 18.1 months in the 20mg group.Results demonstrated significant within-group increases in forward flexion, external rotation, and internal rotation in both groups, with no significant between-group differences. In patients with... Read More »
Level 1 RCT
3%
Synopsis: Six randomized controlled trials (231 patients) were included in this analysis comparing short-term pain and functional outcome between a specific exercise program and general exercise program in the management of patients with subacromial impingement syndrome.Compiling data at 4-8 week follow-up, results demonstrated no significant differences between the two strategies in pain during activity, or in functional outcome. Further high-quality trials... Read More »
Level 1 Meta Analysis
3%
Synopsis: 50 patients with Dupuytren’s contracture were randomized to treatment with either collagenase clostridium histolyticum injection or percutaneous needle fasciotomy.Patients were assessed for rates of clinical improvement, clinical success, recurrence, and adverse events at 30 days, 1-year, and 2 years after treatment.Both groups demonstrated an early 30-day clinical improvement, however, the rate of clinical improvements and success in both groups declined at 1 and 2 years.There were no significant differences between groups in clinical improvement or success over the 2-year follow-up.The recurrence rate at 2 years was 83% in the collagenase group and 68% in the fasciotomy group. Collagenase injections were... Read More »
Level 2 RCT
2%
Synopsis: 28 randomized controlled trials assessing the effect of exercise interventions on the walking ability of patients with knee osteoarthritis were included in this meta-analysis.The purpose of this study was to quantitatively compare exercise therapy to a control group receiving no intervention or psychoeducational interventions (in terms of total distance walked, amount of time spent walking, and gait speed).The results displayed that the exercise intervention significantly improved total distance walked, the amount of time spent walking, and gait velocity when compared to control. It was noted... Read More »
Level 1 Meta Analysis
2%
Synopsis: 56 patients with pes anserinus tendino-bursitis were randomized to two treatment groups: one group received 3 weeks of kinesiotaping, while the other received 10 days of naproxen 250mg three times daily plus daily physical therapy sessions.The purpose of this study was to compare pain, swelling, and adverse events from pre- to post-treatment.Results demonstrated a significant reduction in pain and swelling in both groups, though reductions were significantly greater in the KT group compared to the NSAID plus PT group. Adverse events were... Read More »
Level 2 RCT
2%
Synopsis: Seven randomized controlled trials evaluating the efficacy of exercise therapy and/or manual therapy relative to control intervention for patients with hip osteoarthritis were included in this meta-analysis.Control groups among the included studies ranged from usual care from general practitioners, patient education, and waiting list control.High-quality evidence indicated that exercise therapy significantly improved pain and physical function post-treatment and at follow-up compared to control interventions. While manual therapy... Read More »
Level 2 Meta Analysis
2%
Synopsis: 41 patients with primary frozen shoulder who received treatment with hydrodilatation were randomized to either participate in a 4-week supervised physiotherapy program afterward in addition to a home exercise therapy program, or to home exercises alone.Patients were assessed for shoulder function on the Oxford Shoulder Score, pain, and range of motion at 4 weeks, 3 months, 6 months, and 12-month follow-up. Results demonstrated no... Read More »
Level 2 RCT