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55%
13%
13%
5%
5%
3%
2%
2%
1%
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100%
7%
Synopsis: 40 patients with a symptomatic partial supraspinatus tear were randomized to receive a subacromial injection of either platelet-rich plasma or corticosteroid (triamcinolone acetonide).The purpose of this study was to compare clinical, functional, and radiological outcomes at 6-week, 12-week, and 6-month follow-up between groups. Results demonstrated significantly... Read More »
Author verified Level 2 RCT
6%
Synopsis: 140 patients with Kellgren-Lawrence grade II-III knee osteoarthritis were randomized to a single intra-articular injection of either corticosteroid or hyaluronic acid.The purpose of this study was to compare clinical outcome measures (VAS pain; WOMAC; KOOS) between groups at 1, 2, and 3 months post-injection.The only significant difference between groups observed was significantly lower VAS pain in the CS group compared to the HA group at 1 month. All other measures... Read More »
RCT
6%
Synopsis: 140 patients with symptomatic knee osteoarthritis (Kellgren-Lawrence grade II-III) and ultrasonographic evidence of synovitis were included in this trial to determine the effects of prolonged corticosteroid use on cartilage loss and pain.Patients were randomized to injections of triamcinolone acetonide or saline every 12 weeks for a period of two years.The outcomes assessed included cartilage loss and damage (MRI), pain, function, and adverse events. The results of... Read More »
Level 1 RCT
4%
Synopsis: 74 patients with plantar fasciitis were randomized to treatment with either extracorporeal shockwave therapy (ESWT) or botulinum toxin type A (BoNT-A) injections.The purpose of this study was to compare pain on a visual analog scale (VAS), Roles and Maudsley pain scores, plantar fasciitis thickness on ultrasound, and the incidence of adverse events.Patients were followed-up at 1 month.The ESWT group demonstrated a greater reduction in VAS pain at rest and on the Roles and Maudsley score compared to the BoNT-A injections. No significant difference... Read More »
Author verified Level 2 RCT
4%
Synopsis: 100 patients were randomized to evaluate the comparative efficacy of hyaluronic acid and corticosteroid injections in the treatment of knee osteoarthritis.Follow-up was conducted over 6 months.Results indicated that there was no difference between groups in terms of pain relief and improvement in function.Men appeared to have a better response than women to both treatments. Read More »
Level 2 RCT
3%
Synopsis: 11 randomized controlled trials were included in this traditional meta-analysis and network meta-analysis comparing the efficacy of intra-articular injections of hyaluronic acid (IA-HA), corticosteroids (IA-CS), and placebo (IA-P) in the treatment of patients with mild-moderate knee osteoarthritis.The primary end point was the treatment response rate according to the Outcome Measures in Rheumatoid Arthritis Clinical Trials-Osteoarthritis Research Society International (OMERACT-OARSI) criteria, and the secondary end points included standard mean differences in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, function, and stiffness scores.All data came between 8 and 26 weeks post-injection time points.Network meta-analysis demonstrated significance in favour of IA-HA over both IA-CS and IA-P regarding OMERACT-OARSI response rate and WOMAC function scores, and, additionally, significance in favour of IA-HA over IA-P in WOMAC pain scores.No significant difference between treatments was observed in network meta-analysis of WOMAC stiffness scores. Based on the... Read More »
Author verified Level 1 Meta Analysis
3%
Synopsis: 42 patients with radigographically verified degenerative osteoarthritis (OA) of the knee were randomized to receive either hyaluronan or triamcinolone injection treatment.This study assessed the efficacy of hyaluronan and triamcinolone injections for the treatment of OA, while also comparing outcome measures of these two treatments.The results from this study indicated that both injections provide a number of improvements from baseline measures, including VAS pain scores, Knee Society Scores and in a number of others. There were no... Read More »
Level 1 RCT
3%
Synopsis: 40 knee osteoarthritis (OA) patients were randomized to undergo treatment with intra-articular injections of either sodium hyaluronate (NaHA) or 6-methylprednisolone (6-MPH).The purpose of the study was to compare the two interventions in terms of pain, stiffness, function, and tolerability.Although significantly greater benefits were reported for pain outcomes in patients undergoing treatment with NaHA, stiffness and function remained comparable between the groups. The treatment was... Read More »
Level 2 RCT
3%
Synopsis: 222 patients with OARSI grades 1-3 knee osteoarthritis were randomized to intra-articular viscosupplementation with either an intermediate-molecular-weight hyaluronic acid plus mannitol, an antioxidant, (HAnOX-M), or high-molecular-weight hyaluronic acid (Bio-HA).The purpose of this study was to evaluate if the HAnOX-M group demonstrated non-inferior results on Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain and Function sub-scores compared to the Bio-HA group over 26-week follow-up. Results suggested non-inferiority... Read More »
Author verified Level 2 RCT
3%
Synopsis: 442 patients suffering from unilateral knee pain were randomized to evaluate the safety and efficacy of 26 weeks of a single-injection of intra-articular non-animal stabilized hyaluronic acid (NASHA) compared to methylprednisolone acetate (MPA).Following 26 weeks of blinded evaluation, patients were offered a second injection with NASHA and were followed for an additional 26 weeks.The evidence presented in this study demonstrated that NASHA gel produced a non-inferior response rate in comparison to MPA.WOMAC pain, physical function, and stiffness evaluations favored NASHA over MPA during the blinded phase from 12 to 26 weeks.Sustained improvements were apparent in WOMAC outcomes irrespective of initial treatment in response to open-labeled extension with NASHA. No serious device-related... Read More »
Author verified Level 1 RCT