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39%
23%
20%
7%
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13%
Synopsis: Five randomized controlled trials were included in this meta-analysis which sought to investigate the efficacy of mesenchymal stem cell injections in patients with knee osteoarthritis.Included studies featured various control groups, including placebo injection, hyaluronic acid injection, and no injection, as well as various concomitant treatments, including high tibial osteotomy, microfracture, platelet rich plasma injection and hyaluronic acid injection.Accordingly, clinical heterogeneity was assumed.Data was pooled from 12-24 month time points. Analyses on visual... Read More »
Level 2 Meta Analysis
11%
Synopsis: 60 patients with Kellgren-Lawrence grade I-II knee osteoarthritis were randomized to treatment with either intraarticular hyaluronic acid or oral hyaluronic acid.Patients allocated to IAHA were administered three weekly injection, and patients allocated to oral HA were given daily tablets to take for 40 days.Outcome measures included pain on a visual analog scale and the American Knee Society Score. Within-group improvement from... Read More »
Level 2 RCT
9%
Synopsis: 84 adult patients with symptomatic isolated interstitial supraspinatus tears were randomized to receive infiltration with platelet rich plasma (PRP) or normal saline.A total of two injections were administered separated by 1 month.The primary outcome of interest was the change in lesion volume.Secondary outcomes of interest included pain on a Visual Analog Scale (VAS), the Single Assessment Numerical Evaluation (SANE), Constant score, the American Shoulder and Elbow Surgeons (ASES) score, the incidence of adverse events and the performance of surgical repair.Follow up was performed at 7 and 12 months after the first injection.Results revealed no significant differences between the PRP and control groups in the change in lesion volume, VAS pain, SANE score, Constant score, and ASES score.The incidence of adverse events was significantly higher in the PRP group. No significant difference... Read More »
Level 1 RCT
5%
Synopsis: 148 patients with knee osteoarthritis were randomized to ten, 10-minute sessions over two weeks of either simultaneous ultrasound and transcutaneous electrical nerve stimulation or ultrasound alone.Patients were assessed primarily for pain in six separate measures: total pain; pain during walking; pain during stair climbing; pain at night; pain at rest; and pain during weight-bearing. Results in all... Read More »
Level 2 RCT
4%
Synopsis: 14 studies, including 8 randomized controlled trials, were included in this meta-analysis which had the purpose of evaluating the prophylactic effects of preventative neuromuscular training in female athletes afflicted with anterior cruciate ligament injuries.The four types of exercise in the training program – balance, proximal control, strength, and plyometrics – were evaluated in subgroup analyses to determine efficacy in terms of number of anterior cruciate ligament injuries incurred during the intervention.The results of this study indicated that strength and proximal control training offered the greatest benefits in terms of preventing injury.However, no significant reduction was seen in the incidence of injuries in patients who engaged in balance or plyometric activities in comparison to those who did not. Additionally, subgroup analysis... Read More »
Author verified Level 2 Meta Analysis
3%
Synopsis: 60 patients with low back pain and lumbar radiculopathy were randomized to a 2-week physiotherapy program with or without the addition of spinal mobilization technique in sessions with physiotherapists.To be enrolled, patients had to have demonstrated a positive response to a trial application of spinal mobilization.Patients were assessed for outcome related to leg pain, back pain, disability and function after 2 weeks, 3 months, and 6 months. Results demonstrated better... Read More »
Level 2 RCT
3%
Synopsis: 105 patients post-total knee arthroplasty were randomized to either the addition hip abductor specific strengthening exercises or general functional exercises to a standard postoperative rehabilitation protocol.Patients were assessed primary for outcome on the Knee Injury and Osteoarthritis Outcome Score (symptoms, pain, ADL, and QoL scales) and hip abduction strength after 6 and 26 weeks.Results for the primary outcomes demonstrated no significant differences between groups for improvement in any of the outcome measures after 6 and 26 weeks. Results on secondary... Read More »
Level 2 RCT
2%
Synopsis: 10 randomized or quasi-randomized controlled trials were included in this direct meta-analysis and indirect network meta-analysis comparing the results of corticosteroid injection, autologous whole blood injection (AB), and platelet-rich plasma injection (PRP) in the treatment of patients with lateral epicondylitis.The results fo this study indicated that by final follow-up, which ranged from 2-12 months post-injection, both direct and indirect analyses favoured pain and disability results with platelet-rich plasma versus corticosteroid, while only indirect analyses favoured autologous whole blood over corticosteroid. No significant differences... Read More »
Level 2 Meta Analysis
2%
Synopsis: 70 patients, 18 years of age or older, with knee osteoarthritis were randomized to three weekly intraarticular injections of either high molecular weight hyaluronic acid or low molecular weight hyaluronic acid.Patients were assessed of outcome, primarily related to pain and treatment response, on visual analog scales.Both patient- and evaluator-rated assessments were completed.For weight-bearing pain, improvement from baseline to 12 weeks was significant greater in the HMW HA group, as judged by both patients and evaluators. For treatment response,... Read More »
RCT
2%
Synopsis: 105 patients diagnosed with mild-to-moderate knee osteoarthritis were randomized to receive an intra-articular injection of botulinum toxin type A (BTA), triamcinolone hexacetonide (TH) or 0.9% saline.The primary outcome of interest was pain during movement, measured on a Visual Analog Scale (VAS).Secondary outcomes of interest included VAS pain at rest, the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index, the short form 36 (SF-36) quality of life questionnaire, the 6 minute walk test (6MWT), the timed up and go (TUG) test, range of motion (ROM) in flexion and extension, synovial hypertrophy and the incidence of adverse events.Follow up was performed at 4, 8 and 12 weeks post-injection.VAS pain during motion was significantly different among the three groups, with the TH group displaying the most favourable outcomes. There were no... Read More »
Level 1 RCT