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Synopsis: Five randomized controlled trials were included in this meta-analysis which sought to investigate the efficacy of mesenchymal stem cell injections in patients with knee osteoarthritis.Included studies featured various control groups, including placebo injection, hyaluronic acid injection, and no injection, as well as various concomitant treatments, including high tibial osteotomy, microfracture, platelet rich plasma injection and hyaluronic acid injection.Accordingly, clinical heterogeneity was assumed.Data was pooled from 12-24 month time points. Analyses on visual... Read More »
Level 2 Meta Analysis
4%
Synopsis: 39 patients with distal radius fractures undergoing open reduction and internal fixation (ORIF) with a volar locking plate were randomized to receive 2 weeks of post-operative immobilization with a plaster splint or no immobilization.The primary outcome of interest was pain as measured on a Visual Analog Scale.Secondary outcomes included tramadol (opioid) use, DASH score, range of motion (wrist flexion-extension; forearm rotation), patient satisfaction, wrist edema and incidence of complications.Follow up was performed up to 6 months. The results from... Read More »
Level 2 RCT
3%
Synopsis: 60 patients with Kellgren-Lawrence grade I-II knee osteoarthritis were randomized to treatment with either intraarticular hyaluronic acid or oral hyaluronic acid.Patients allocated to IAHA were administered three weekly injection, and patients allocated to oral HA were given daily tablets to take for 40 days.Outcome measures included pain on a visual analog scale and the American Knee Society Score. Within-group improvement from... Read More »
Level 2 RCT
2%
Synopsis: 84 adult patients with symptomatic isolated interstitial supraspinatus tears were randomized to receive infiltration with platelet rich plasma (PRP) or normal saline.A total of two injections were administered separated by 1 month.The primary outcome of interest was the change in lesion volume.Secondary outcomes of interest included pain on a Visual Analog Scale (VAS), the Single Assessment Numerical Evaluation (SANE), Constant score, the American Shoulder and Elbow Surgeons (ASES) score, the incidence of adverse events and the performance of surgical repair.Follow up was performed at 7 and 12 months after the first injection.Results revealed no significant differences between the PRP and control groups in the change in lesion volume, VAS pain, SANE score, Constant score, and ASES score.The incidence of adverse events was significantly higher in the PRP group. No significant difference... Read More »
Level 1 RCT
2%
Synopsis: 23 randomized controlled trials were included in this meta-analysis which compared component alignment, operative time, length of stay and blood loss between cases of total knee arthroplasty completed with patient-specific instrumentation and cases completed with conventional instrumentation.Absolute deviation and incidence of outliers did not significantly differ between groups for overall coronal lower limb alignment, coronal and sagittal femoral component alignment, and coronal and sagittal tibial component alignment.While absolute deviation in axial femoral component alignment was lower among PSI groups, the difference between groups in outliers in axial femoral component alignment was not significant.Operative time was statistically significantly shorter among PSI groups by approximately 7.5 minutes, and blood loss was statistically significantly lower among PSI groups by approximately 83mL. Length of stay... Read More »
Level 1 Meta Analysis
1%
Synopsis: 135 patients admitted for total knee replacement were randomized to receive patient controlled analgesia with morphine with either an additional continuous femoral nerve block (FNB), an additional single-shot femoral nerve block, or control (no femoral nerve block).The primary outcome of interest was quadriceps strength recovery (QSR).Secondary outcomes of interest included pain on a Visual Analog Scale (VAS), knee range of motion, thigh diameter, the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index, the Short Form 36 (SF-36) questionnaire, opioid consumption and length of stay.Follow up was performed during inpatient stay, and at 6 weeks, 6 months and 12 months.Results revealed significantly favourable quadriceps recovery in closed chain contractions at all time points, and in open chain reactions at 6 weeks, in favour of the control group.Knee range of motion was significantly in favour of the control group.No significant differences in morphine consumption, length of stay, thigh diameter, VAS pain score, or SF-36 scores were observed among the three groups. Patients in the... Read More »
Level 2 RCT
1%
Synopsis: 105 patients post-total knee arthroplasty were randomized to either the addition hip abductor specific strengthening exercises or general functional exercises to a standard postoperative rehabilitation protocol.Patients were assessed primary for outcome on the Knee Injury and Osteoarthritis Outcome Score (symptoms, pain, ADL, and QoL scales) and hip abduction strength after 6 and 26 weeks.Results for the primary outcomes demonstrated no significant differences between groups for improvement in any of the outcome measures after 6 and 26 weeks. Results on secondary... Read More »
Level 2 RCT
1%
Synopsis: 148 patients with knee osteoarthritis were randomized to ten, 10-minute sessions over two weeks of either simultaneous ultrasound and transcutaneous electrical nerve stimulation or ultrasound alone.Patients were assessed primarily for pain in six separate measures: total pain; pain during walking; pain during stair climbing; pain at night; pain at rest; and pain during weight-bearing. Results in all... Read More »
Level 2 RCT
1%
Synopsis: 97 patients scheduled for total hip arthroplasty and managed with a multimodal analgesia regimen were randomized to either receive or not received intravenous acetaminophen over the first 24 hours postoperatively.Primary purpose of this study was to examine and compare pain scores between groups, as well as assess opioid consumption and incidence of postoperative nausea and vomiting.These outcomes were assessed over the first 24 hours after surgery. Results demonstrated significantly... Read More »
Level 2 RCT
1%
Synopsis: 100 patients scheduled for unilateral total hip arthroplasty (THA) were randomized to receive analgesic peri-articular cocktail injection containing ropivacaine, epinephrine, ketoprofen, methylprednisolone sodium, and normal saline, with or without the addition of morphine.The primary outcomes of interest were pain at rest and during motion, measured on a Visual Analog Scale (VAS).Secondary outcomes of interest included nausea on a numeric rating scale (NRS), the number of vomiting cases per person, anti-emetic drug consumption, levels of hemoglobin and C-reactive protein (CRP), range of motion in flexion and abduction, thigh swelling, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the incidence of complications.Results revealed no significant differences in VAS pain scores, both at rest and during movement, between the morphine and control groups.NRS nausea scores in the first hour post-operation, as well as total metoclopramide consumption, was significantly higher in the morphine group. No significant differences... Read More »
Level 1 RCT