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4%
Synopsis: 82 patients, 40-80 years of age, with knee osteoarthritis were randomized to treatment with either hyaluronic acid injections or a physical therapy program.Patients allocated to hyaluronic acid injections were administered either high-molecular-weight HA (Hylan G-F20) or low-molecular-weight HA (Orthovisc). Results demonstrated significant... Read More »
RCT
4%
Synopsis: 90 patients scheduled for total knee arthroplasty were randomized to one of three nerve block combinations for postoperative analgesia: an obturator nerve block (ONB) plus continuous adductor canal block (cACB), a tibial nerve block (TNB) plus cACB, or an ONB and TNB plus cACB.Patients were assessed primarily for patient-controlled analgesia consumption, time to first analgesia request, and pain scores postoperatively. Results for morphine... Read More »
Level 1 RCT
2%
Synopsis: 90 patients with chronic ankle instability were randomized to either 3 weeks of joint mobilization treatment, 3 weeks of sham mobilization treatment, or no intervention.Patients were assessed following the completion of one session, at the completion of the 3-week treatment phases, and at 6-month follow-up after the completion of treatment for range of motion in dorsiflexion, the Cumberland Ankle Instability Tool, and the Star Excursion Balance Test in the anterior, posteromedial, and posterolateral directions.Results significantly favoured the mobilization group compared to both sham and control groups after 3 weeks and at 6-month follow-up outcome for all measures. Additional, range of... Read More »
Level 2 RCT
2%
Synopsis: 166 patients with an intra-articular distal radius fracture were randomized to fixation with either a volar locking plate or an external fixator.Patients were followed from 6 weeks to 2 years after surgery.Results demonstrated significantly favourable results for the VLP group compared to the EF group for the Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH score) and range of motion in flexion, extension, pronation, and supination from 6 weeks to 1 year. By 2 years,... Read More »
Level 2 RCT
2%
Synopsis: 61 patients with Kellgren-Lawrence grade II-III knee osteoarthritis were randomized to treatment with either a single intraarticular injection of bone morrow-derived mesenchymal stem cells (BM-MSC) or oral acetaminophen 500mg every 8 hours for 6 months.Patients were assessed for outcome on a visual analog scale for pain and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).Patients were assessed 1 week, 1 month and 6 month follow-up. Results demonstrated significantly... Read More »
Level 2 RCT
1%
Synopsis: 310 patients with Kellgren-Lawrence grade II-III knee osteoarthritis were randomized to a single intraarticular injection of either extended release triamcinolone acetonide 16mg (FX006 16mg; Flexion Therapeutics), extended release triamcinolone acetonide 32mg (FX006 32mg; Flexion Therapeutics), or placebo saline.Patients were assessed for the primary outcome measure of pain on a Numeric Rating Scale weekly for 24 weeks, with the primary endpoint at 12 weeks.At the primary endpoint, neither the FX006 16mg group nor the FX006 32mg group demonstrated significantly lower pain scores compared to the placebo group.At secondary endpoints, significantly lower NRS score was noted with FX006 16mg vs placebo for weeks 1-9, and with FX006 32mg vs placebo from weeks 1-11 and week 13.Differences between groups at all subsequent timepoints were not significant. Read More »
Level 2 RCT
1%
Synopsis: 62 patients scheduled for arthroscopic shoulder surgery were randomized to receive an ultrasound guided supra-clavicular brachial plexus block (SCBB) or an interscalene brachial plexus block (ISBB) for pain relief following surgery.The primary outcome of interest was pain intensity within the first 24 hours post-operation, measured on a Visual Analog Scale (VAS).Secondary outcomes included the proportion of patients requiring additional analgesics, time to first analgesic requirement, nerve blockade characteristics (scanning time, needling time, procedural time, onset time of sensory block, block failure) and adverse events.Results from the study revealed no significant differences between groups in VAS pain scores up to 12 hours.However at 24 hours, VAS pain score was significantly higher in the ISBB group.Additionally, the proportion of patients with Horner's syndrome was significantly higher in the ISBB group. There were no... Read More »
Level 1 RCT
1%
Synopsis: 240 patients scheduled for short intramedullary nail fixation for an intertorchanteric fracture were randomized to one of three distal locking configurations: static locked, dynamic locked, or unlocked.Patients were assessed for intraoperative variables - including operative and fluoroscopy times, blood loss, and transfusion rate - and postoperative outcomes related to fracture healing, function, pain, and complications.Results demonstrated significant differences only in operative variables, with operative time, fluoroscopy time, and blood loss favoured in the unlocked group compared to the two distal locking groups. Postoperative outcomes did... Read More »
Author verified Level 2 RCT
1%
Synopsis: 102 patients with carpal tunnel syndrome were randomized to receive either an ultrasound-guided or landmark-based corticosteroid injection.Outcomes of interest included the Boston Carpal Tunnel Questionnaire (BCTQ) Symptom and Function scores, grip strength, rate of surgical treatment following injection, and adverse events.Follow up was performed at 4, 12 and 24 weeks.The results of the study revealed a favourable BCTQ symptom score at 4 weeks in the ultrasound-guided group compared to the landmark-based group.Furthermore, a higher proportion of patients in the landmark-based group displayed adverse events compared to the ultrasound-guided group. Otherwise, there were... Read More »
Level 2 RCT
1%
Synopsis: 80 patients with a displaced distal radius fracture were randomized to primary treatment through either palmar plate fixation or cast immobilization.Patients were assessed over 2-year follow-up, which included patient-reported disability (Disabilities of the Arm, Shoulder, and Hand [DASH]), wrist range of motion, grip strength, adverse events, and cases of secondary surgery.A total of 18/42 patients assigned to cast immobilization demonstrated loss of fracture reduction; 16 of these patients underwent secondary palmar plating.At 2 years, DASH score was significantly lower in the palmar plate group compared to the cast immobilization group.In subgroup analysis, the significant difference between groups when considering patients <65 years of age, but not in patients 65 years of age or older. Significant differences between... Read More »
Level 2 RCT