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Synopsis: Five randomized controlled trials were included in this meta-analysis which sought to investigate the efficacy of mesenchymal stem cell injections in patients with knee osteoarthritis.Included studies featured various control groups, including placebo injection, hyaluronic acid injection, and no injection, as well as various concomitant treatments, including high tibial osteotomy, microfracture, platelet rich plasma injection and hyaluronic acid injection.Accordingly, clinical heterogeneity was assumed.Data was pooled from 12-24 month time points. Analyses on visual... Read More »
Level 2 Meta Analysis
5%
Synopsis: 29 studies were included in this meta-analysis comparing operative and non-operative treatment for acute Achilles tendon ruptures.The primary outcome of interest was the rate of re-rupture.Secondary outcomes included the rate of complications, functional outcomes, time to return to sports and time to return to work.The results revealed a significantly lower rate of re-rupture, but a higher rate of complications, in the operative group compared to the non-operative group.Similar findings to the primary analyses were observed in the sensitivity analyses based on early and late weight bearing status, high quality studies and studies conducted after the year 2000.There were no significant differences in re-rupture rate in studies utilizing accelerated functional rehabilitation. There was no... Read More »
Level 1 Meta Analysis
2%
Synopsis: 28 subjects with frozen shoulder syndrome (FSS) were randomized to undergo one of two multiple treatment trials for the treatment of FSS.The three techniques involved in the treatment trials were end-range mobilization (ERM), mid-range mobilization (MRM), and mobilization with movement (MWM). The primary outcome... Read More »
Level 2 RCT
2%
Synopsis: In this meta-analysis 4 randomized controlled trials and 8 cohort studies (total of 610 patients) examining the joint preservation and arthroplasty methods for displaced proximal humerus fractures were evaluated to determine which type of treatment was more effective. Following comparisons of outcomes from treatment methods, results indicated that joint preservation provided a significantly larger improvement in mean Constant scores than arthroplasty. Read More »
Conference Report
2%
Synopsis: Data from 12 studies (4 RCTs; 8 cohort studies), spanning 610 patients was analyzed in order to compare joint-preserving techniques and arthroplasty in the treatment of 3- and 4-part proximal humerus fractures.The evidence presented in this meta-analysis/systemic review indicated that joint-preserving treatments demonstrated higher Constant scores than arthroplasty.It is important to note that the included studies exhibited significant heterogeneity. Constant scores were... Read More »
Author verified Level 2 Meta Analysis
2%
Synopsis: 150 female patients scheduled for anterior cruciate ligament (ACL) reconstruction were randomized to undergo surgery using either a hamstring autograft (HS group) or bone-patellar tendon-bone autograft (BPTB group).The purpose of this study was to compare clinical scores, knee laxity, and rate of graft failure over 2 years of follow-up.The results suggested no significant difference between groups in Lysholm score, side-to-side difference in knee laxity, or the rate of re-arthroscopy and graft failure.The BPTB group demonstrated a higher rate of patients experiencing severe anterior knee pain (visual analog scale >3) within the first 6 months, though pain was similar between groups at 2 years. Read More »
Level 2 RCT
2%
Synopsis: 9 studies (8 RCTs, 1 controlled clinical trial) were selected for a systematic review of elderly patients with a proximal humerus fracture.The goal of this study was to determine whether surgical or nonoperative treatment is the optimal intervention in patients over the age of 60.Operative treatments identified in the included trials were the tension band technique, locking plates, pinning and hemiarthroplasty.The results of this review indicated that many studies did not find a significant difference in functional outcomes when comparing locking plates or tension bands to nonoperative treatment at 1 year.There was a significantly better health-related quality of life and Euroqol-5D in patients that received a hemiarthroplasty compared to the nonoperative group for patients with 4-part fractures.Complications were common in the operative treatment groups. This study highlights... Read More »
Level 2 Meta Analysis
2%
Synopsis: 5 randomized control trials (RCTs) comparing surgical and non-surgical treatment of displaced 3 or 4-part fractures of the proximal humerus were included in this meta-analysis.The purpose of this study was to determine how patient outcome differed depending on whether a surgical or non-surgical method was used for the treatment of a fracture.Functional outcome was the primary outcome of interest, while quality of life and complication rates were assessed as secondary outcomes.Results indicated no significant difference between groups in terms of functional outcome. Pooled analysis of... Read More »
Level 2 Meta Analysis
2%
Synopsis: 72 patients with a displaced 2- or 3-part proximal humerus fracture were randomized to operative management through either intramedullary nail fixation or locking plate fixation.The purpose of this study was to compare clinical outcome scores between groups, as well as radiographic results and complications, over 12 month follow-up postoperatively.Findings demonstrated no significant differences between groups in Constant and Murley Score, Disabilities of the Arm, Shoulder, and Hand (DASH) score, visual analog scale pain scores, shoulder range of motion, or radiographic results (union and head shaft angle) at 3, 6, or 12 months. Significantly higher incidences... Read More »
Conference Report
2%
Synopsis: 154 female cancer survivors were randomized to receive either a 12-month aerobic-resistance exercise program or a home-based exercise regimen.The purpose of this study was to compare bone outcomes following the two treatments to determine their effect on bone loss in this patient population.Both groups experienced significant losses in bone mineral density at multiple sites over the 12 months study period.No significant differences were observed between groups in the change in bone mineral density at the lumbar spine, greater trochanter, hip, or femoral neck. Subgroup analyses found... Read More »
Level 2 RCT