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Synopsis: 60 patients with lateral epicondylitis were randomized to an injection into the extensor carpi radialis brevis (ECRB) of either botulinum toxin type A (BoNT-A) or placebo.Patients were assessed after 30 and 90 days.The primary outcome was the rate of patients who experienced a minimum 50% reduction in pain on a visual analog scale.Additional outcomes investigated included the rate of patients who experienced interference with daily activities, sporting events, and professional activities, the incidence of side effects, and the rate of patients who requested additional treatment after 90 days was documented.Results demonstrated a significantly higher rate of patients in the BoNT group compared to the placebo group who experienced 50% or more reduction in pain after 90 days.Other outcomes which significantly favoured the BoNT-A group were interference with daily activities or rate of request for subsequent treatment. The rate of... Read More »
Author verified Level 1 RCT
3%
Synopsis: 180 patients scheduled for arthroscopic rotator cuff repair were randomized to postoperative analgesia for 2 weeks using either celecoxib 200mg, ibuprofen 385mg, or tramadol 50mg.Primary study variables included pain scores and rescue analgesia consumption over the first 2 weeks.Secondary study variables, implemented a posteriori, were pain scores, functional scores, and tendon healing on the Sugaya classifications over a 24-month follow-up.Primary study variables demonstrated no significant differences between groups.Secondary study variables also demonstrated no significant differences between groups, with the exception of retear rate. Retear rate was... Read More »
Level 1 RCT
1%
Synopsis: 1583 patients with symptomatic knee osteoarthritis were randomized to either glucosamine monotherapy, chondroitin monotherapy, combined glucosamine and chondroitin therapy, celecoxib 200mg daily, or placebo.Patients were assessed over 24 weeks of treatment.In the primary analysis, only the celecoxib group demonstrated a significantly higher rate of patients attaining the primary efficacy endpoint - a reduction of WOMAC pain by a minimum of 20% relative to baseline - compared to placebo. However, when only... Read More »
RCT
1%
Synopsis: 30 patients scheduled for anterior cruciate ligament (ACL) reconstruction were randomized to either receive or not receive a femoral nerve block for postoperative analgesia.The purpose of this study was to compare isokinetic quadriceps strength – relative to the healthy knee (limb symmetry index) – and patient-reported outcome on the Knee Injury and Osteoarthritis Outcome Score (KOOS) between groups at 6 weeks and 6 months postoperatively. The results on... Read More »
Level 2 RCT
1%
Synopsis: 390 novice distance runners were randomized to 2 weeks of either a gait re-training program on an instrumented treadmill with real-time visual feedback or control intervention of simple treadmill running.Outcomes recorded included vertical average loading rate (VALR) and vertical instantaneous loading rate (VILR) while running at 8km/h and 12km/h.Runners were also assessed for the incidence of running-related injury over the following 12 months after the intervention period.Results demonstrated significantly lower VALR and VILR at both 8km/h and 12km/h paces in the gait re-training group compared to the control group. The overall incidence... Read More »
Level 2 RCT
1%
Synopsis: 254 patients with symptomatic lumbar spinal stenosis were randomized to undergo decompression with or without interlaminar stabilization with the coflex ILS device (Paradigm Spine).The primary outcome was a composite endpoint of clinical success over a 2-year follow-up.Results demonstrated a significantly higher rate of attaining the composite endpoint for clinical success in the group which received interlaminar stabilization compared to the group that did not. No significant differences... Read More »
Level 2 RCT
1%
Synopsis: 32 patients with osteochondral lesions of the talus, that were unresponsive to other non-operative treatment modalities, were randomized to injections with platelet-rich plasma (PRP) using a plasma rich in growth factors technique (PRGF) or hyaluronic acid (HA). Follow-up at 4, 14, and 28 weeks after the injection indicated that PRP is a safe and efficacious treatment for osteochondral lesions producing a number superior clinical and subjective results when compared to HA. Read More »
Author verified Level 2 RCT
1%
Synopsis: 22 randomized controlled trials were included in this network meta-analysis, that included over 10 injectable treatments, to evaluate comparative efficacy for the management of plantar faciopathy.The primary outcome of this study was pain relief.At 0-2 month follow-up, micronized dehydrated human amniotic/chorionic membrane was the most likely treatment to be effective for pain relief.At 2-6 months, botulinum toxin A was the treatment most likely to be effective for pain relief, while a treatment most likely to be effective beyond 12 months could not be identified from the limited amount of evidence available at this time point.The lack of trials available was a limiting factor of this network meta-analysis, exemplified by the lack of studies reporting data on micronized dehydrated human amniotic/chorionic membrane beyond 2 months. Further trials are... Read More »
Level 1 Meta Analysis
1%
Synopsis: 100 patients scheduled for reverse total shoulder arthroplasty were randomized to receive a prosthesis with either a 135-degree neck-shaft angle or a 155-degree neck-shaft angle.Patients were assessed for clinical scores and incidence of complications over 1 year postoperatively.Results demonstrated no significant differences in shoulder range of motion, patient-reported pain or function between groups after 1 year. The incidence of... Read More »
Conference Report
1%
Synopsis: 48 patients with calcific tendinitis of the rotator cuff were randomized to an ultrasound-guided subacromial corticosteroid injection (SAIC) injection with or without additional ultrasound-guided barbotage.Patients were assessed for functional scores and rate of secondary intervention (barbotage or surgery) over 5-year follow-up. Results demonstrated a... Read More »
Level 1 RCT