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16%
Synopsis: 112 patients with a single-level disc herniation were randomized to undergo either microendoscopic discectomy or open (fenestration/laminotomy) discectomy either posterior lumbar interbody fusion or posterolateral fusion, to compare the safety and efficacy of the treatment methods.Following radiographic and clinical evaluations over a 12 month period, the results indicated that radicular pain was reduced equally by the two methods, but that the length of hospital stay was shorter and blood loss was lower for the Microendoscopic Discectomy group. However, due to... Read More »
Author verified Level 2 RCT
16%
Synopsis: 78 patients with painful osteoporotic vertebral fractures were randomized to receive a vertebroplasty spinal procedure or placebo approach, with the purpose of comparing clinical outcomes between treatments up to two years.Results indicated no significant between group differences in overall pain (primary outcome) and all other secondary outcomes at the 12-and 24-month follow-up assessments.Risk of developing clinical vertebral fractures was similar between groups, although this study was not adequately powered for this outcome. Routine vertebroplasty is... Read More »
Author verified Level 2 RCT
16%
Synopsis: 50 patients with single-level cervical radiculopathy presenting with chronic neck pain and undergoing anterior cervical discectomy and fusion (ACDF) were randomized to receive either a standalone anchored polyetheretherketone (PEEK) cage (PREVAIL) or a PEEK cage with plating.The purpose of the study was to compare clinical and radiological outcomes between groups over 2 year follow-up.The results indicated that the stand-alone anchored PEEK device provided comparable clinical and radiograpahical outcomes to that of PEEK cage with anterior plating. Dysphasia rate was... Read More »
Level 2 RCT
16%
Synopsis: 58 patients with low back pain due to degenerative lumbar disease were randomized to intradiscal injection of 1-2mL of either platelet-rich plasma (PRP) or contrast agent (Omnipaque 180).The purpose of this study was to evaluate the efficacy of PRP for improvement of measures of pain and function relative to a nonactive injection.Follow-up was performed over 8 weeks post-injection. Results after 8... Read More »
Level 2 RCT
16%
Synopsis: 554 patients with a lumbar disc herniation, large annular defect, and scheduled for lumbar discectomy were randomized to the surgery with or without additional intervention using an annular closure device (Barricaid; Intrinsic Therapeutics).Patients were followed primary for the incidence of re-herniation and composite endpoints of success over the first 2 years after surgery.Results demonstrated a significantly lower rate of subsequent symptomatic lumbar disc re-herniation at the index level among the group treated with the annular closure device. In addition, the... Read More »
Level 2 RCT
16%
Synopsis: 77 patients with lumbar disc herniation between L3-5 and scheduled for discectomy were randomized to surgery with or without the addition of an interspinous spacer (Wallis dynamic stabilization system; Zimmer).Patients were assessed for clinical and radiographic outcome after 3 years.At 3 years, no significant differences between groups were noted in pain scores on a visual analog scale, the Japanese Orthopaedic Association score, or the Oswestry Disability Index (ODI).Disc height at 3 years was significantly greater in the interspinous spacer group, however. There was no... Read More »
Level 2 RCT
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