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23%
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2%
Synopsis: 82 patients, 40-80 years of age, with knee osteoarthritis were randomized to treatment with either hyaluronic acid injections or a physical therapy program.Patients allocated to hyaluronic acid injections were administered either high-molecular-weight HA (Hylan G-F20) or low-molecular-weight HA (Orthovisc). Results demonstrated significant... Read More »
RCT
2%
Synopsis: 310 patients with Kellgren-Lawrence grade II-III knee osteoarthritis were randomized to a single intraarticular injection of either extended release triamcinolone acetonide 16mg (FX006 16mg; Flexion Therapeutics), extended release triamcinolone acetonide 32mg (FX006 32mg; Flexion Therapeutics), or placebo saline.Patients were assessed for the primary outcome measure of pain on a Numeric Rating Scale weekly for 24 weeks, with the primary endpoint at 12 weeks.At the primary endpoint, neither the FX006 16mg group nor the FX006 32mg group demonstrated significantly lower pain scores compared to the placebo group.At secondary endpoints, significantly lower NRS score was noted with FX006 16mg vs placebo for weeks 1-9, and with FX006 32mg vs placebo from weeks 1-11 and week 13.Differences between groups at all subsequent timepoints were not significant. Read More »
Level 2 RCT
2%
Synopsis: 61 patients with Kellgren-Lawrence grade II-III knee osteoarthritis were randomized to treatment with either a single intraarticular injection of bone morrow-derived mesenchymal stem cells (BM-MSC) or oral acetaminophen 500mg every 8 hours for 6 months.Patients were assessed for outcome on a visual analog scale for pain and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).Patients were assessed 1 week, 1 month and 6 month follow-up. Results demonstrated significantly... Read More »
Level 2 RCT
2%
Synopsis: 72 patients with knee osteoarthritis were randomized to intraarticular injection with either 40mg methylprednisolone or 30m ketorolac.Patients were assessed for improvement over 6-week follow-up in numeric rating scale (NRS) pain scores, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the Oxford Knee Score (OKS).Results demonstrated significant significant within-group improvement in both groups for NRS pain score and WOMAC scores. However, for OKS... Read More »
Conference Report
2%
Synopsis: 43 patients with a partial- or full-thickness rotator cuff tear were randomized to nonoperative treatment with either a suprascapular nerve block or subacromial injection.Patients were assessed for outcome on a modified Constant score at 2, 6, and 12 weeks after treatment. While no significant... Read More »
Level 2 RCT
2%
Synopsis: 192 patients with knee osteoarthritis were randomized to three weekly intraarticular injections with either platelet-rich plasma or hyaluronic acid.The focuse of the current study was outcome after 2 and 5 years following treatment.Results for clinical outcome on the International Knee Documentation Committee (IKDC) subjective score, the EuroQoL 5-dimensions (EQ-5D) and the Tegner activity scale demonstrated no significant differences between the PRP group and HA group at 2 or 5 years.Within the first 2 years of treatment, rate of reintervention, including either repeat injection therapy or surgery, was significantly lower in the PRP group compared to the HA group. However, at 5... Read More »
Level 1 RCT
2%
Synopsis: 90 patients scheduled for total knee arthroplasty were randomized to one of three nerve block combinations for postoperative analgesia: an obturator nerve block (ONB) plus continuous adductor canal block (cACB), a tibial nerve block (TNB) plus cACB, or an ONB and TNB plus cACB.Patients were assessed primarily for patient-controlled analgesia consumption, time to first analgesia request, and pain scores postoperatively. Results for morphine... Read More »
Level 1 RCT
2%
Synopsis: 102 patients with carpal tunnel syndrome were randomized to receive either an ultrasound-guided or landmark-based corticosteroid injection.Outcomes of interest included the Boston Carpal Tunnel Questionnaire (BCTQ) Symptom and Function scores, grip strength, rate of surgical treatment following injection, and adverse events.Follow up was performed at 4, 12 and 24 weeks.The results of the study revealed a favourable BCTQ symptom score at 4 weeks in the ultrasound-guided group compared to the landmark-based group.Furthermore, a higher proportion of patients in the landmark-based group displayed adverse events compared to the ultrasound-guided group. Otherwise, there were... Read More »
Level 2 RCT
1%
Synopsis: 13 ACE reports (4 reviews/ meta-analyses, 9 RCTs) were included from the OrthoEvidence database that compared operative versus nonoperative or operative versus operative treatments for displaced midshaft clavicle fractures.The findings of this review demonstrated that surgical procedures led to a lower rate of nonunion and malunion with better functional outcome when compared to nonoperative treatment. Comparisons of operative treatments indicated that an optimal surgical procedure - between plate fixation, nailing, and pin fixation - could not be determined based on union rates or functional outcome. The results of... Read More »
ACE Review
1%
Synopsis: Six randomized controlled trials were included in this meta-analysis evaluating the efficacy of platelet-rich plasma injections for the treatment of acute muscle injuries.Among all studies, time to return to sport was significantly shorter following PRP injection versus control treatment. In contrast, in... Read More »
Author verified Level 1 Meta Analysis