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4%
Synopsis: 106 patients with resistant multiple sclerosis who had demonstrated adequate treatment response to Sativex (tetrahydrocannabinol and cannabidiol oromucosal spray) treatment in a 4-week trial phase were randomized to Sativex or placebo for 12 weeks after 1-4 week washout from the trial phase.The purpose of the study was to determine if tetrahydrocannabinol and cannabidiol oromucosal spray (THC:CBD group) significantly improve spasticity, pain, spasm frequency and severity, sleep disruption quality of life, and functional performance compared to placebo.The modified Ashworth scale, and Expanded Disability Status Scale were also used as outcome measures. Results indicate that... Read More »
Author verified Level 2 RCT
4%
Synopsis: The authors performed a systematic review and meta-analysis of five randomized controlled trials, all of which compared intra-articular viscosupplementation to placebo for patients with hip osteoarthritis.They had a total sample size of 591 patients followed at 3 different time points: 7-14 days, 28-30 days, and final follow-up.Outcomes included pain (Numeric Rating Scale, Visual Analogue Scale, and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain score) and function (WOMAC Function and Lequesne). Though some studies... Read More »
Level 1 Meta Analysis
2%
Synopsis: 53 patients with primary adhesive capsulitis (frozen shoulder) were randomized to manipulation under anesthesia (MUA) or steroid injection combined with shoulder distension.The most efficacious treatment for frozen shoulder is still controversial topic; therefore, this study assessed two common treatments to determine the superior treatment.The results indicated that at 2 year follow-up, there were no differences in pain and functional outcomes between the two groups. The authors advised... Read More »
Level 2 RCT
2%
Synopsis: 74 patients who underwent arthroscopic ACL reconstruction were randomized to receive either a neuromuscular exercise (NE) program or a standard strength exercise (SE) program.This study compared subjective and objective outcomes at 6 month, 1 and 2 year follow-ups.Significantly improved knee function was found in the NE group at 6 month follow-up, but this difference diminished with further long term follow-ups. The SE group... Read More »
Author verified Level 2 RCT
2%
Synopsis: 178 subjects were randomized to one of two treatment groups or a control group.One group received custom-made in-shoe orthoses, the second group received ready-made in-shoe orthoses, and the third group did not receive any orthoses (control).Outcomes of pain, gross motor skills, exercise efficiency and self-perception were examined.Results from this study did not provide evidence to justify in-shoe orthoses for the management of flexible excess foot pronation in children ages 7-11. No significant differences... Read More »
Level 2 RCT
2%
Synopsis: 283 patients with disc herniation and resulting sciatica were randomized to either receive early surgery or prolonged conservative treatment for 6 months (followed by surgery if needed).The results indicated that for both groups, similar outcomes were observed at the one year follow up period. However it is... Read More »
Author verified Level 2 RCT
2%
Synopsis: 501 patients with intervertebral disc herniation were randomized to receive standard open discectomy with examination of the irritated nerve root or non-operative care.Symptom severity improved significantly more in the surgery group than the non-operative group at 3 months, 1 year and 2 years.Self-reported improvement was also significantly better in the surgery group than in the non-operative group.There were slight but non-significant differences in favour of the surgery group over 2 years for pain, function, disability scores, and patient satisfaction. Although several significant... Read More »
Level 2 RCT
2%
Synopsis: This meta-analysis and systematic review included 193 studies (84 randomized controlled trials were assessed in the meta-analysis) comparing physical therapy to a control group in patients with knee osteoarthritis (OA).The most effective interventions were ultrasonography, and aerobic, aquatic, strengthening, and proprioception exercise.Education, orthotics, taping, tai chi, and pulsed electromagnetic fields had no clinically significant effect on any of the patient-centered or functional outcomes of interest. Few adverse events... Read More »
Author verified Level 1 Meta Analysis
2%
Synopsis: 165 patients were randomized to determine the efficacy of a single corticosteroid injection in treating lateral epicondylalgia, both in the presence and absence of physiotherapy.Patients were allocated to one of four groups: corticosteroid with physio, corticosteroid without physio, placebo with physio, or placebo without physio. The results at... Read More »
Author verified Level 2 RCT
2%
Synopsis: Findings of two randomized controlled trials were pooled in order to investigate if method of corticosteroid injection - either image-guided or anatomical landmark guided (blind) - impacted clinical outcome in patients suffering from shoulder pain.Clinical outcomes of pain and function were reported at 6 weeks, and the incidences of adverse events were recorded.Pooled effects illustrated that pain and function at 6 weeks were significantly improved with image-guided injections compared to blind injections. Incidence of adverse... Read More »
Level 1 Meta Analysis