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32%
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13%
8%
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100%
7%
Synopsis: 604 patients with symptomatic knee osteoarthritis were randomized to treatment with either chondroitin sulfate, celecoxib, or placebo over a 6 month period.Patients were assessed for pain, function, perceived improvement and adverse events over the 6 months.The results from this study indicated that all three groups demonstrated a significant improvement from baseline over the 6 months.Both the chondroitin sulfate group and the celecoxib group demonstrated significantly greater improvement in pain and function compared to the placebo group after 6 months.There were no significant differences between the chondroitin sulfate group and the celecoxib group for pain or function. Incidence of adverse... Read More »
Author verified Level 2 RCT
4%
Synopsis: 140 patients with symptomatic knee osteoarthritis (Kellgren-Lawrence grade II-III) and ultrasonographic evidence of synovitis were included in this trial to determine the effects of prolonged corticosteroid use on cartilage loss and pain.Patients were randomized to injections of triamcinolone acetonide or saline every 12 weeks for a period of two years.The outcomes assessed included cartilage loss and damage (MRI), pain, function, and adverse events. The results of... Read More »
Level 1 RCT
3%
Synopsis: 10 studies (5 randomized controlled trials (RCTs)) assessing the effects of electrical stimulation on bone healing following spinal fusion in comparison to a placebo or a control were identified for inclusion in this 2002 meta-analysis.The purpose of this study was to quantitatively assess the available body of evidence regarding the effect of electrical stimulation on bone healing (union) following spinal fusion.Only the 5 RCTs were included in statistical pooling of findings.The results indicated that electrical stimulation resulted in more successful fusion rates when compared to the placebo/control group. However, limited evidence... Read More »
Author verified Level 2 Meta Analysis
3%
Synopsis: 222 patients with OARSI grades 1-3 knee osteoarthritis were randomized to intra-articular viscosupplementation with either an intermediate-molecular-weight hyaluronic acid plus mannitol, an antioxidant, (HAnOX-M), or high-molecular-weight hyaluronic acid (Bio-HA).The purpose of this study was to evaluate if the HAnOX-M group demonstrated non-inferior results on Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain and Function sub-scores compared to the Bio-HA group over 26-week follow-up. Results suggested non-inferiority... Read More »
Author verified Level 2 RCT
3%
Synopsis: 74 patients with plantar fasciitis were randomized to treatment with either extracorporeal shockwave therapy (ESWT) or botulinum toxin type A (BoNT-A) injections.The purpose of this study was to compare pain on a visual analog scale (VAS), Roles and Maudsley pain scores, plantar fasciitis thickness on ultrasound, and the incidence of adverse events.Patients were followed-up at 1 month.The ESWT group demonstrated a greater reduction in VAS pain at rest and on the Roles and Maudsley score compared to the BoNT-A injections. No significant difference... Read More »
Author verified Level 2 RCT
2%
Synopsis: Six ACE Reports were identified from the OrthoEvidence database which compared intra-articular injection(s) of hyaluronic acid to corticosteroid in the treatment of osteoarthritis of the knee.All of the included studies were randomized controlled trials which reported pain and/or functional outcomes within 6 months of intervention.Pooled analysis of pain on a visual analog scale indicated that pain relief was significantly better with hyaluronic acid injections at both 3 and 6 months follow-up; however, this finding was strongly influenced by two studies of lower methodological quality. No significant differences between hyaluronic acid and corticosteroid injections were observed in any functional outcome measurement.Due to incomplete or lack of reporting adverse events, an assessment of safety could not be performed along with this review. Furthermore, these findings... Read More »
ACE Review
2%
Synopsis: 40 patients with a symptomatic partial supraspinatus tear were randomized to receive a subacromial injection of either platelet-rich plasma or corticosteroid (triamcinolone acetonide).The purpose of this study was to compare clinical, functional, and radiological outcomes at 6-week, 12-week, and 6-month follow-up between groups. Results demonstrated significantly... Read More »
Author verified Level 2 RCT
1%
Synopsis: 40 patients with neck pain or radicular symptoms in the upper extremity undergoing anterior cervical discectomy were randomised to undergo the procedure with carbon fiber cage alone or allograft with plating (using the Smith-Robinson technique).The primary outcomes were based on clinical and radiographic evaluation. The results indicated... Read More »
Level 2 RCT
1%
Synopsis: 110 postmenopausal osteoporotic women with chronic low back pain were randomised to receive either an intranasal salmon calcitonin with oral calcium intervention or an oral calcium intervention only.The patients were part of three groups, based on the presence of vertebral fractures, degenerative disorders, or non specific chronic back pain with no evidence of vertebral deformities.The primary outcome was back pain and disability. The results indicated... Read More »
Level 2 RCT
1%
Synopsis: 21 patients with lumbar radiculopathy due to a herniated nucleus pulposus or spinal stenosis were included in a study investigating the effects of selective nerve root blocks in the lumbar spine on preventing the need for operative treatment.Patients had been randomized in a prior study, that included 55 patients, to receive bupivacaine alone or bupivacaine and betamethasone.29 of these patient avoided surgey and 21 on were available to be followed up at 5 years.After 5 years, there was no difference between the two groups for the proportion of patients who did not require surgery.17 of 21 patients receiving a nerve root injection who did not require surgery at 1 year continued to 5 years without needing operative intervention. All patients who... Read More »
Level 2 RCT