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6%
Synopsis: 111 patients with Kellgren-Lawrence grade I-IV symptomatic knee osteoarthritis were randomized to three weekly intraarticular injections of either leukocyte-poor platelet-rich plasma (LP-PRP) or hyaluronic acid.Patients were assessed for pain and function over a 52-week follow-up.The primary outcome measure, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score, demonstrated no significant difference between groups at any time point.In contrast, pain scores on a visual analog scale (VAS) demonstrated significantly lower pain in the LP-PRP group compared to the HA group at 24- and 52-week follow-up. Similarly International Knee... Read More »
Author verified Level 2 RCT
3%
Synopsis: 18 randomized controlled trials were included in this network meta-analysis to evaluate the effect of platelet-rich plasma injections in the management of tendinopathies and if outcomes are affected by the type of preparation.The results from this study indicate that platelet-rich plasma is an effective treatment for tendinopathies and that leukocyte-rich platelet-rich plasma preparations appear to have the greatest effect. However, further trials... Read More »
Author verified Level 2 Meta Analysis
2%
Synopsis: 41 patients with isolated acute or subacute primary ligamentous Lisfranc injuries were randomised to undergo either a primary open reduction and internal fixation procedure or a primary partial arthrodesis procedure.Short- and long-term functional and clinical outcomes were examined. The results indicated... Read More »
Level 2 RCT
2%
Synopsis: 107 patients scheduled for two-stage revision hip or knee arthroplasty due to periprosthetic infection have been included in this randomized controlled trial to evaluate the efficacy of a 3-month course of oral antibiotics in reducing the rate of reinfection.The results reported in this summary are from a planned interim analysis conducted when the trial reached half of its planned sample size.Patients were randomized to a receive an additional 3-month course of oral antibiotics tailored to the original infecting organism or no additional antibiotic treatment.The incidence of reinfection was significantly lower in the oral antibiotics group compared to the control group (p=0.0162), suggesting that a course of oral antibiotics following two-stage revision hip and knee arthroplasty may reduce the risk of recurrent periprosthetic infection. However, given that... Read More »
Author verified RCT
1%
Synopsis: 32 patients (25 at last follow-up) with acute tarsometatarsal joint fractures or fracture dislocations were randomized to receive primary arthrodesis (PA) or primary open reduction and internal fixation (PORIF).This study evaluated whether the PA procedure produced improved functional outcomes and fewer secondary surgeries.The results at all-time points (3, 6, 12, 24 months) indicated that there were no physical function differences reported for Short Form-36 (SF- 36) and Short Musculoskeletal Function Assessment (SMFA) scores. The PA procedure... Read More »
Level 2 RCT
1%
Synopsis: 245 patients with chronic plantar fasciitis were randomized to 3 sessions of radial extracorporeal shock wave therapy (ESWT) or placebo treatment. At 12 weeks and 12 months, the radial ESWT significantly improved the pain, function, and quality of life compared with placebo in patients with recalcitrant plantar fasciitis. Read More »
Author verified Level 1 RCT
1%
Synopsis: 109 patients with a moderate, dorsally displaced distal radius fracture (Colles') were randomized to two different conservative management protocols after closed reduction.One group was treated with plaster cast immobilization for 10 days followed by elastic bandaging, while the other group was treated with 1 month (range 4-5 weeks) of plaster cast immobilization. Radiographic results found... Read More »
Author verified Level 2 RCT
1%
Synopsis: 248 patients with symptomatic knee osteoarthritis were randomized to one of three treatment groups: topical diclofenac sodium gel, a vehicle-control group that administered only the carrier solution, and a placebo group.Patients were to apply the allocated interventions for 4 weeks.Patients were assessed for outcome on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), a Patient Global Assessment, and the Incidence of adverse events. After 4 weeks,... Read More »
RCT
1%
Synopsis: 53 patients undergoing shoulder arthroscopy for complete rotator cuff tears were randomized to receive either intraoperative platelet-rich plasma (PRP) application or control (standard surgery without PRP), in order to test the hypothesis that PRP can improve tendon healing in these patients.Short-term functional recovery and pain was improved in the PRP group, but differences were not significant by the 2 year follow-up. Healing rates between... Read More »
Author verified Level 1 RCT
1%
Synopsis: 101 patients with an acute grade 1 or 2 ankle sprain were randomized to be managed with an early therapeutic exercise program or a conventional PRICE (protection, rest, ice, compression and elevation) protocol.It was observed that after early incorporating therapeutic exercises during the first week after an ankle sprain brings about significant improvements in physical activity and improved functional status compared to the standard treatment at weeks 1 and 2. At 16-week follow-up,... Read More »
Author verified Level 2 RCT