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PeerView

You are viewing the most viewed ACE Reports by Physiotherapists over the last 30 days in all specialties.

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Synopsis: 16 patients with osteoarthritis of the medial tibiofemoral compartment and valgus knee alignment were included in this crossover randomized trial to assess the effect of custom-fit valgus knee braces and custom-made lateral wedge foot orthotics when used concurrently and individually on external knee adduction moment during gait.Patients were randomized to undergo gait testing using a motion capture system under 4 conditions: a combination of both knee brace and orthotic, knee brace only, orthotic only, and control (no intervention).The results of the trial indicated that the use of both interventions concurrently had the greatest effect in reducing the knee adduction moment compared to the control. There was no... Read More »
Level 2 RCT
6%
Synopsis: 381 participants with vertebral compression fractures were randomized to receive either balloon kyphoplasty or vertebroplasty as treatment.The purpose of this study was to compare the safety and efficacy of the two treatments.The results indicated that the two procedures provided similar outcomes in terms of pain, disability, and quality of life over the next 2 years.Mean procedure duration was longer and there was lower cement extravasation in the kyphoplasty group.This study was terminated by the sponsor with only 404 patients out of the 1234 sample size goal (32.7%) due to high rates of withdrawal and limited enrollment. Further evaluations that... Read More »
Author verified Level 2 RCT
5%
Synopsis: 303 patients with peripheral neuropathic pain (PNP) were randomized to either Nabiximols or placebo for 14 weeks.Significant improvements in pain, quality of sleep and Subject Global Impression of Change (SGIC) were found in patients that received Nabiximols compared to those that received placebo. No patients experienced... Read More »
Level 1 RCT
3%
Synopsis: 44 patients who underwent either TKA or THA (31 of whom completed the study) were randomized to receive either a fixed dose of morphine/oxycodone, a flexible dose of morphine/oxycodone or oxycodone/acetaminophen to compare the efficacy of these analgesic treatments.Results indicated that the morphine/oxycodone flexible dose group experienced a 20% decrease in the time-weighted sum of pain intensity difference from 0 to 48 hours (SPID-48) and 3 times less moderate to severe adverse gastrointestinal events when compared to the oxycodone/acetaminophen group. Read More »
Level 2 RCT
2%
Synopsis: Six ACE Reports were identified from the OrthoEvidence database which compared intra-articular injection(s) of hyaluronic acid to corticosteroid in the treatment of osteoarthritis of the knee.All of the included studies were randomized controlled trials which reported pain and/or functional outcomes within 6 months of intervention.Pooled analysis of pain on a visual analog scale indicated that pain relief was significantly better with hyaluronic acid injections at both 3 and 6 months follow-up; however, this finding was strongly influenced by two studies of lower methodological quality. No significant differences between hyaluronic acid and corticosteroid injections were observed in any functional outcome measurement.Due to incomplete or lack of reporting adverse events, an assessment of safety could not be performed along with this review. Furthermore, these findings... Read More »
ACE Review
2%
Synopsis: 66 patients with central neuropathic pain due to multiple sclerosis (MS) were randomly assigned to receive either cannabis-based medicine (CBM) through oromucosal spray or placebo for 4 weeks.Participants were assessed on pain severity, sleep disturbances, the impression of change, the incidence of adverse events, cognitive abilities, mood, and MS-related disability at the beginning and end of the study.Results demonstrated that oromucosal administration of CBM was effective in improving pain, sleep disturbance compared to placebo. The incidence of... Read More »
Level 1 RCT
2%
Synopsis: 55 patients with HIV-associated sensory neuropathy (HIV-SN) were randomly assigned to receive either one 0.9g cigarette (3.56% delta-9-tetrahydrocannabinol) per day for 5 days, or its respective placebo with the identical schedule.Patients were assessed on pain on Visual Analogue Scale (VAS), hyperanalgesia, pain to heat stimulation, and incidence and severity of adverse events daily for 12 days.Results showed that smoked cannabis was effective in reducing pain and hyperanalgesia, but had an insignificant effect on pain to heat stimulation. Despite eliciting greater... Read More »
Level 1 RCT
1%
Synopsis: Six ACE Reports (5 randomized controlled trials and 1 systematic review/meta-analysis) were identified from the OrthoEvidence database which evaluated the efficacy of platelet-rich plasma in the treatment of knee osteoarthritis.All included studies were randomized controlled trials, and reported clinical and functional assessment at various time points between 1 and 6 months following treatment.Pooled analysis of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Total scores suggested a possible beneficial effect with PRP injection in comparison to saline and a lower effect versus hyaluronic acid.Beneficial effects were also noted for individual subscales of the WOMAC assessment (pain, stiffness, and physical function).However, pooling of OMERACT-OARSI responders and a review of the literature indicated that there was no significant difference between PRP and comparison groups in other functional outcome measures, such as the International Knee Documentation Committee (IKDC) assessment and Knee Injury and Osteoarthritis Outcome Score (KOOS).Furthermore, contrasting results were obtained between two studies reporting function on the Lequesne Index. The discrepancy in... Read More »
ACE Review
1%
Synopsis: 8 ACE Reports (all randomized controlled trials) from the OrthoEvidence database were included in this review/meta-analysis examining the effect of arthroscopic surgery and physical therapy in the treatment of degenerative tears of the meniscus and knee osteoarthritis.The purpose of this review was to determine if any differences in outcome were demonstrated between arthroscopy followed by physical therapy versus physical therapy alone, regarding pain, function, satisfaction, adverse events, or osteoarthritis progression.Pain results were pooled at 3 different time point: 2-3 months, 6 months, and 12-24 months postintervention.At short-term (2-3 months) and long-term (12-24 months) follow-up, pain was similar between groups, with no significant difference observed.There tended to be less pain experienced at 6 months following arthroscopy, however this only reached significance in the KOOS pain outcome and the clinical importance of this observation is unknown.Assessments of functional outcome, either pooled or qualitative, suggested no significant difference between groups as well. The rate of... Read More »
ACE Review
1%
Synopsis: A total of 7 RCTs were included in this systematic review which aimed to investigate the efficacy of progressive resistance training (PRT) before and after total hip arthroplasty (THA) and total knee arthroplasty (TKA) when compared to a control group.The analysis was based on muscle strength, functional capacity, quality of life, and the incidence of adverse events. Preoperative progressive resistance... Read More »
Level 3 Meta Analysis