Knee OA - The therapeutic trajectory of corticosteroids and hyaluronic acid

Arthritis Rheum. 2009 Dec 15;61(12):1704-11

Differences in hyaluronic acid characteristics influence outcomes in knee OA patients

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Hyaluronic acid versus corticosteroid in the treatment of knee osteoarthritis

Comparison of combined hyaluronic acid (HA) and corticosteroid vs. HA alone injection for knee OA

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Efficacy of hyaluronic acid vs placebo for pain relief in knee OA; meta-analysis of RCTs

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Intra-articular hyaluronic acid provides longer pain relief as compared to corticosteroid

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Hyaluronic acid did not yield superior outcomes for hip osteoarthritis

Arthritis Rheum. 2009 Mar;60(3):824-30

Single injection of hyaluronic acid not recommended for ankle osteoarthritis treatment

J Bone Joint Surg Am. 2012 Jan 4;94(1):2-8

Hyaluronic acid improves pain in patients with hip osteoarthritis at 3-month evaluation

J Arthroplasty. 2015 Mar;30(3):507-511.

Improvement of condition with hyaluronic acid injection for ankle OA

Arch Phys Med Rehabil. 2013 May;94(5):951-60. doi: 10.1016/j.apmr.2012.10.030. Epub 2012 Nov 10

Small effect of hyaluronic acid for pain relief in treatment of knee osteoarthrits

JAMA. 2003 Dec 17;290(23):3115-21

Hyaluronic acid and exercise therapy, in combination or as monotherapy, for knee OA

Knee Surg Sports Traumatol Arthrosc. 2016 May;24(5):1686-94

Hyaluronic acid with and without additional dexamethasone injection for knee OA

Curr Med Res Opin. 1992;13(1):49-55

Hyaluronic acid compared to placebo safely improves pain and function in OA patients

Clin Med Insights Arthritis Musculoskelet Disord. 2013 Sep 1;6:57-63

Similar 3-month efficacy for single-injection corticosteroid & hyaluronic acid in knee OA

Springerplus. 2016 Apr 12;5:442

Consistent pain improvement from 4-24 weeks with hyaluronic acid in knee osteoarthritis

Osteoarthritis Cartilage. 2011 Jun;19(6):611-9

No clinically important effects of hyaluronic acid injection in knee osteoarthritis

J Bone Joint Surg Am. 2015 Dec 16;97(24):2047-60

Improved articular cartilage repair with combined stem cell and hyaluronic acid injection

Arthroscopy. 2013 Apr;29(4):684-94. doi: 10.1016/j.arthro.2012.12.008. Epub 2013 Feb 4

Platelet-rich plasma improves WOMAC scores compared to hyaluronic acid in knee OA

Electron Physician. 2016 Mar 25;8(3):2115-22. doi: 10.19082/2115. eCollection 2016.

Conflicts of interest: effect on conclusions of hyaluronic acid trials for knee OA

J Arthroplasty. 2013 Sep;28(8 Suppl):30-33