No clinically important effects of hyaluronic acid injection in knee osteoarthritis

Study Type:Meta-analysis/Systematic Review

OE Level Evidence:2

Journal Level of Evidence:1

Viscosupplementation for Osteoarthritis of the Knee: A Systematic Review of the Evidence

J Bone Joint Surg Am. 2015 Dec 16;97(24):2047-60

Contributing Authors: D Jevsevar P Donnelly GA Brown DS Cummins

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Synopsis

19 randomized controlled trials (4485 patients) analyzing the effects of hyaluronic acid injection on pain, function and stiffness in knee osteoarthritis patients were included. The purpose of this meta-analysis was to determine the clinical significance of hyaluronic acid and which trial factors influence the treatment effects on pain, function, and stiffness. The results displayed that double-bl...