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RCT
ACE Report #8156
Ace Report Cover Osteoarthritis

Hyaluronic acid injection similar in symptom & structure of knee OA vs diacerein & placebo


Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Evaluation of the symptomatic and structural efficacy of a new hyaluronic acid compound, NRD101, in comparison with diacerein and placebo in a 1 year randomised controlled study in symptomatic knee osteoarthritis

Ann Rheum Dis. 2004 Dec;63(12):1611-7

Contributing Authors: T Pham A Le Henanff P Ravaud P Dieppe L Paolozzi M Dougados

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Synopsis

301 patients, over 50 years of age, with knee osteoarthritis, were randomized to receive either oral diacerein treatment (100mg/day) and 3 courses of intra-articular saline injections, oral placebo (100mg/day) and 3 courses of intra-articular saline injections, or oral placebo (100mg/day) and 3 courses of intra-articular hyaluronic acid injections (NRD101). The purpose of the study was to compare ...

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