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General Orthopaedics

Effect of Bamlanivimab (LY-CoV555) Antibody Treatment on Viral Load & Clinical Outcomes for COVID-19

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November 2020
General Orthopaedics

Effect of Bamlanivimab (LY-CoV555) Antibody Treatment on Viral Load & Clinical Outcomes for COVID-19

Vol: 9| Issue: 11| Number:21| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19

N Engl J Med. 2020 Oct 28.

Contributing Authors:
P Chen A Nirula J Morris B Heller RL Gottlieb J Boscia G Huhn B Mocherla V Stosor AC Adams J Van Naarden KL Custer L Shen M Durante G Oakley AE Schade J Sabo DR Patel P Klekotka DM Skovronsky BLAZE-1 Investigators

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Synopsis

Four hundred and fifty two patients who tested positive for coronavirus disease 19 (COVID19) were randomized to receive a single intravenous infusion of LY-CoV555, at a dose of 700mg, 2800mg, or 7000mg, or placebo, for the reduction of viral load and amelioration of symptoms. The primary outcome of interest was the change from baseline in viral load at 11 days follow up. Secondary outcomes of inte...

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