As of our updated search performed in April 2023, OE M.I.N.D. contains data from nearly 3,944 RCTs related to knee conditions with over 1,747,858 patients.

• For patients with anterior cruciate ligament (ACL) injury, early reconstruction was associated with superior outcomes in Tegner activity score, stability, re-injury and revision surgery compared to rehabilitation alone either up to 2 years or longer than 2 years follow-up.
• There was no significant difference between surgical and non-surgical treatment in composite clinical outcomes, pain, and incidence of return to preinjury activity level during follow-up periods of either up to 2 years or 2 to 15 years post treatment.
• In terms of either reconstruction or rehabilitation for ACL injury, a total of 47 studies were found to be currently ongoing around the world, aiming to recruit over 12,000 patients based on data from clinicaltrials.gov.
• Since 2005, the manufacturers that have published the most research associated with reconstruction for ACL are Smith & Nephew, Arthrex, DePuy Synthes, Ethicon and Mitek.