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ACE Report #9357
Ace Report Cover Osteoarthritis

Hyaluronic acid plus mannitol versus HMW HA in knee OA treatment

Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Safety and efficacy of intra-articular injections of a combination of hyaluronic acid and mannitol (HAnOX-M) in patients with symptomatic knee osteoarthritis: Results of a double-blind, controlled, multicenter, randomized trial

Knee. 2016 Oct;23(5):842-8

Contributing Authors: T Conrozier F Eymard N Afif JC Balblanc V Legré-Boyer X Chevalier Happyvisc Study Group

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222 patients with OARSI grades 1-3 knee osteoarthritis were randomized to intra-articular viscosupplementation with either an intermediate-molecular-weight hyaluronic acid plus mannitol, an antioxidant, (HAnOX-M), or high-molecular-weight hyaluronic acid (Bio-HA). The purpose of this study was to evaluate if the HAnOX-M group demonstrated non-inferior results on Western Ontario and McMaster Univer...

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