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Hyaluronic acid reduces IL-6, no change observed in IL-8 and TNF-a levels in knee OA
January 2016
Hyaluronic acid reduces IL-6, no change observed in IL-8 and TNF-a levels in knee OA
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A
Does hyaluronan affect inflammatory cytokines in knee osteoarthritis?
Rheumatol Int. 2005 May;25(4):264-9Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
41 patients were randomized to three weekly injections of either hyaluronic acid (Orthovisc) or placebo (0.9% NaCl). The purpose of this study was the evaluate and compare cytokine levels - interleukin-6, interleukin-8, and tumour necrosis factor-alpha - in the synovial fluid between groups at one week after the completion of treatment. Additionally, the Western Ontario McMaster Universities Osteo...
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