Hyaluronic acid reduces IL-6, no change observed in IL-8 and TNF-a levels in knee OA
Does hyaluronan affect inflammatory cytokines in knee osteoarthritis?Rheumatol Int. 2005 May;25(4):264-9
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41 patients were randomized to three weekly injections of either hyaluronic acid (Orthovisc) or placebo (0.9% NaCl). The purpose of this study was the evaluate and compare cytokine levels - interleukin-6, interleukin-8, and tumour necrosis factor-alpha - in the synovial fluid between groups at one week after the completion of treatment. Additionally, the Western Ontario McMaster Universities Osteo...
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