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RCT
ACE Report #8164
Ace Report Cover Osteoarthritis

Hyaluronic acid reduces IL-6, no change observed in IL-8 and TNF-a levels in knee OA


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Does hyaluronan affect inflammatory cytokines in knee osteoarthritis?

Rheumatol Int. 2005 May;25(4):264-9

Contributing Authors: M Sezgin AC Demirel C Karaca O Ortancil GB Ulkar A Kanik A Cakçi

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Synopsis

41 patients were randomized to three weekly injections of either hyaluronic acid (Orthovisc) or placebo (0.9% NaCl). The purpose of this study was the evaluate and compare cytokine levels - interleukin-6, interleukin-8, and tumour necrosis factor-alpha - in the synovial fluid between groups at one week after the completion of treatment. Additionally, the Western Ontario McMaster Universities Osteo...

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