Efficacy of polynucleotide solution vs hyaluronic acid for knee osteoarthritis

Study Type:Therapy

OE Level Evidence:1

Journal Level of Evidence:N/A

A randomized double-blind clinical trial on the treatment of knee osteoarthritis: the efficacy of polynucleotides compared to standard hyaluronian viscosupplementation

Knee. 2014 Jun;21(3):661-8

Contributing Authors: LS Giarratana BM Marelli C Crapanzano SE De Martinis L Gala M Ferraro N Marelli W Albisetti

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Synopsis

72 patients with knee osteoarthritis were randomized to intra-articular injections of either Condrotide or hyaluronic acid. Condrotide is a gel containing a solution of polynucleotides. The purpose of this study was to compare the efficacy of Condrotide to that of hyaluronic acid (HA), a standard injection therapy for knee osteoarthritis. Assessment of the KOOS and pain was performed at baseline, ...