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Volume:2 Issue:6 Number:6 ISSN#:2563-5476
Author Verified
RCT
ACE Report #6038
Ace Report Cover Metabolic Disorders

Denosumab is superior to alendronate for improving cortical bone porosity post-menopause


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Differing effects of denosumab and alendronate on cortical and trabecular bone

Bone. 2014 Feb;59:173-9. doi: 10.1016/j.bone.2013.11.016. Epub 2013 Nov 22.

Contributing Authors: RM Zebaze C Libanati M Austin A Ghasem-Zadeh DA Hanley JR Zanchetta T Thomas S Boutroy CE Bogado JP Bilezikian E Seeman

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Synopsis

Two hundred and forty-seven post-menopausal women (146 with data at final follow-up) received a subcutaneous injection every 6 months and a pill weekly. These treatments were randomized as follows: Group one received denosumab injections and a placebo pill, Group two received alendronate and a placebo injection and Group three received a placebo injection and pill. The purpose of this trial wa...

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