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Meta-analysis
ACE Report #5502
Ace Report Cover Metabolic Disorders

Zoledronic acid: best overall bisphosphonate treatment for osteoporosis fractures


Study Type:Meta analysis
OE Level Evidence:1
Journal Level of Evidence:N/A

The efficacy of bisphosphonates in the prevention of vertebral, hip, and nonvertebral-nonhip fractures in osteoporosis: a network meta-analysis

Semin Arthritis Rheum. 2011 Feb;40(4):275-84.e1-2.

Contributing Authors: JP Jansen GJ Bergman J Huels M Olson

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Synopsis

8 randomized placebo controlled trials (including over 20,000 patients) that investigated the effects of different bisphosphonate treatments for osteogenesis in postmenopausal women were evaluated with the aim of determining a superior treatment. A network meta-analysis using the Bayesian approach was conducted to analyze the indirect comparisons provided in the study and found that zoledronic aci...

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