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Volume:1 Issue:5 Number:188 ISSN#:2563-5476
Meta-analysis
ACE Report #4415
Ace Report Cover Metabolic Disorders

Denosumab increases bone mass but does not reduce fracture risk compared to alendronate


Study Type:Meta-analysis/Systematic Review
OE Level Evidence:1
Journal Level of Evidence:N/A

Comparison of clinical efficacy and safety between denosumab and alendronate in postmenopausal women with osteoporosis: a meta-analysis

Int J Clin Pract. 2012 Apr;66(4):399-408. doi: 10.1111/j.1742-1241.2011.02806.x. Epub 2012 Feb 7

Contributing Authors: T Lin C Wang XZ Cai X Zhao MM Shi ZM Ying FZ Yuan C Guo SG Yan

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Synopsis

4 randomised control trials were included in this meta-analysis, to compare the effectiveness of 60mg Denosumab subcutaneously per 6 months (Den) to 70mg Alendronate orally per week (Aln) in the treatment of osteoporosis in postmenopausal women. A total of 1952 women were identified that were followed-up for one year. The primary outcomes were the incidence of clinical fractures and bone mineral d...

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