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Volume:2 Issue:4 Number:163 ISSN#:2563-5476
RCT
ACE Report #4367
Ace Report Cover Pediatric Orthopaedics

Canakinumab effective in treating systemic juvenile idiopathic arthritis


How to Cite

OrthoEvidence. Canakinumab effective in treating systemic juvenile idiopathic arthritis. ACE Report. 2013;2(4):163. Available from: https://myorthoevidence.com/AceReport/Report/4367

Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis

N Engl J Med. 2012 Dec 20;367(25):2396-406. doi: 10.1056/NEJMoa1205099

Contributing Authors: N Ruperto HI Brunner P Quartier T Constantin N Wulffraat G Horneff R Brik L McCann O Kasapcopur L Rutkowska-Sak R Schneider Y Berkun I Calvo M Erguven L Goffin M Hofer T Kallinich SK Oliveira Y Uziel S Viola K Nistala C Wouters

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Synopsis

177 patients, suffering from systemic juvenile idiopathic arthritis (JIA) with active systemic features, who had been chosen to participate in two trials between July 2009 and December 2010, were randomised into two groups to either receive canakinumab or a placebo. Patients in Trial 1 received either canakinumab or the placebo for 29 days. Trial 2 incorporated a two-part withdrawal design, which ...

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