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Meta-analysis
ACE Report #4229
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Lumbar fusion: rhBMP-2 reduces rate of fusion failure and reoperation


Study Type:Meta analysis
OE Level Evidence:1
Journal Level of Evidence:N/A

Recombinant human bone morphogenetic protein-2 versus autogenous iliac crest bone graft for lumbar fusion: a meta-analysis of ten randomized controlled trials

Arch Orthop Trauma Surg. 2012 Dec;132(12):1725-40. doi: 10.1007/s00402-012-1607-3. Epub 2012 Sep 1

Contributing Authors: Z Chen G Ba T Shen Q Fu

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Synopsis

This meta-analysis included 10 randomized controlled trials comparing recombinant human bone morphogenetic protein-2 (rhBMP-2) and iliac crest bone graft (ICBG) in patients receiving lumbar fusion. The results from the analysis indicated that the rate of fusion failure was significantly lower in the rhBMP-2 group than in the ICBG group at 6, 12, and 24 months. The rhBMP-2 group was also superior t...

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