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Safety and Efficacy of Duloxetine after Total Knee Arthroplasty: A Meta-Analysis
April 2023
Safety and Efficacy of Duloxetine after Total Knee Arthroplasty: A Meta-Analysis
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Effect of duloxetine on pain relief after total knee arthroplasty: A meta-analysis of randomized controlled trials.
Medicine (Baltimore) . 2023 Mar 10;102(10):e33101.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
In this meta-analysis, six randomized controlled trials compared duloxetine against placebo in patients undergoing primary total knee arthroplasty (TKA). Outcomes of interest were pain measured on a Visual Analog Scale (VAS) at rest and with movement, equivalent morphine consumption, length of stay, and adverse events. Pain scores with movement favored duloxetine at 24 and 72 hours, and 5 days, wh...
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