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Intra-Articular Polynucleotides & Hyaluronic Acid vs Hyaluronic Acid Only for Knee Osteoarthritis
November 2021
Intra-Articular Polynucleotides & Hyaluronic Acid vs Hyaluronic Acid Only for Knee Osteoarthritis
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Randomised, double-blind comparison of a fixed co-formulation of intra-articular polynucleotides and hyaluronic acid versus hyaluronic acid alone in the treatment of knee osteoarthritis: two-year follow-up.
BMC Musculoskelet Disord. 2021 Sep 12;22(1): 773.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
One hundred knee osteoarthritis patients were randomized to receive 3 intra-articular injections of highly-purified polynucleotides plus hyaluronic acid (n=50) or hyaluronic acid alone (n=50). This study was a 2 year follow up to a previously published 1 year follow up interim analysis. The primary outcome of interest was Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain ...
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