One hundred and sixty-two patients undergoing a total joint arthroplasty (TJA; total hip or knee arthroplasty) were randomized to receive one of 3 new wound closure techniques: surgical zipper (n=54), monofilament suture plus adhesive (n=55), or monofilament suture plus polyester mesh with adhesive (n=53). The primary outcome of interest was closure time. Secondary outcomes of interest included peri-operative complication rates, 90-day readmission, and emergency room visit rates. Results revealed no significant differences in closure time between the 3 techniques; however, when analyzing total hip arthroplasty patients, only the closure time was significantly faster in the suture plus adhesive group (p=0.032). No significant differences between groups in the incidence of infection or drainage were observed, and no cases of 90-day readmission or emergency room visits were reported.