A total of 20 randomized controlled trials (RCTs) examining electrical stimulation in bone-related conditions and 29 RCTs examining electrical stimulation in soft-tissue-related conditions were included in this systematic review and meta-analysis. Qualitatively, 75% and 86% of studies included on bone-related and soft-tissue-related conditions, respectively, demonstrated a positive effect of electrical stimulation compared to control. In the meta-analysis of 11 studies evaluating the use of electrical stimulation in bone fracture, a significant effect on union rate was observed for electrical stimulation. In the meta-analysis of 15 studies on electrical stimulation use in soft-tissue management, a statistically significant effect on healing rate was observed with electrical stimulation.