Sixty patients scheduled for an arthroscopic shoulder surgery were included in this study comparing the addition of serratus plane block to interscalene brachial plexus block vs interscalene brachial plexus block alone, with regards to anesthetic consumption and acute post-operative outcomes. Outcomes of interest included fentanyl consumption, both intraoperatively and post-operatively, intraoperative propofol consumption, ketamine consumption, transition to general anesthesia, pain on a Visual Analog Scale (VAS), patient satisfaction, and surgeon satisfaction. Outcomes were assessed up to 24 hours post-operation. Results revealed a statistically significantly lower consumption of fentanyl and propofol intra-operatively in the serratus block group compared to the control group. VAS pain scores in the PACU and up to 24 hours were not statistically significantly different between groups. Fentanyl consumption up to 24 hours post-operation also was not significantly different between the two treatment arms. Similar patient and surgeon satisfaction was observed in both groups.