142 patients who had suffered a traumatic injury within 4 weeks were randomized to receive treatment using either a multidisciplinary intervention (MI), or usual care (UC) to determine the effectiveness of this approach on physical and psychological functioning. Results at 6 months indicated that there was no significant difference in physical or psychological function between the MI and UC groups. However, when the patients at risk for post-traumatic stress disorder (PTSD) and depression were compared to the control group, those in the MI group reported better pain relief and a lower frequency of general physician (GP) visits. Acute post-traumatic adjustment, acute PTSD and depressive symptoms, acute pain and alcohol use were identified as the best predictors of psychological outcomes, mobility, and pain at 6 months.