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Intravenous + Topical Tranexamic Acid for Intramedullary Nailing of the Tibia
January 2024
Intravenous + Topical Tranexamic Acid for Intramedullary Nailing of the Tibia
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Medullary cavity application of tranexamic acid to reduce blood loss in tibial intramedullary nailing procedures-a randomized controlled trial.
Int Orthop. 2023 Aug; 47(8): 2095–2102.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
106 patients undergoing intramedullary nailing of the tibia were randomized to receive either intravenous (IV) + topical intramedullary tranexamic acid (TXA; n=51) or IV TXA alone with intramedullary saline (n=56). The primary outcomes of interest included total blood loss (TBL), hidden blood loss (HBL), and intraoperative blood loss (IBL). Secondary outcomes included C-reactive protein (CRP), int...
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