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100%
3%
Synopsis: One hundred patients with ankle osteoarthritis were randomly assigned to receive either intra-articular platelet-rich plasma injections (PRP; n=48) or intra-articular placebo injections (n=52).The primary outcome was the patient-reported American Orthopaedic Foot & Ankle Society (AOFAS) score over 52 weeks.Secondary outcomes included various patient-reported measures assessing pain, function, quality of life, and indirect costs over the same period.The adjusted between-group difference for the patient-reported AOFAS score at 52 weeks favored the placebo group by 2 points (95% CI, 25 to 2; P = .31).With regards to secondary outcomes, there were no statistically significant between-group differences observed as was measured at 52 weeks post procedure. Overall, this indicates... Read More »
Level 1 RCT
3%
Synopsis: 141 patients undergoing total knee arthroplasty were randomized to receive either a cementless implant (n=76) or a cemented implant (n=65).Outcomes of interest included Oxford Knee Score (OKS), Knee Society Function Score, Forgotten Joint Score (FJS), percentage of normal knee, patient satisfaction, incidence of revision, and the incidence of reoperation.Outcomes were assessed at 2 and 6 years post-operation.There were no differences in all outcomes at 2 and 6 years except for patient satisfaction which was significantly better in the cementless group. The rate of... Read More »
Level 1 RCT
3%
Synopsis: 23 randomized controlled trials (2284 patients) comparing open versus endoscopic techniques for carpal tunnel release in patients with carpal tunnel syndrome were included in this systematic review and meta-analysis.A subgroup analysis was also conducted on single- versus dual-portal endoscopic treatment.The primary outcomes of interest included complication and reoperation rates.Secondary outcomes included operative time, the incidence of scar tenderness and pillar pain, normalized satisfaction scale, the incidence of complete or near complete symptom relief, Boston Carpal Tunnel Questionnaire (BCTQ) symptom and function, and time to return to work.All outcomes were similar between the two groups except for time to return to work and incidence of scar tenderness (dual-portal vs open) which all favored the endoscopic group.The incidence of nerve injury was significantly lower in the open-technique group. Overall, the endoscopic... Read More »
Level 1 Meta Analysis
3%
Synopsis: Two hundred twenty-four patients with knee osteoarthritis were randomized to receive different tibial baseplate fixation methods during total knee arthroplasty (TKA).The patients were assigned to three groups: Group 1 received a cemented tibial component (n=97), Group 2 received a pegged porous cementless tibial component (n=87), and Group 3 received a cementless tantalum monoblock porous tibial component (n=90).The primary outcome of interest was survivorship, and secondary outcomes included functional measures such as the Oxford Knee Score, Knee Society Score, and radiological data.Outcomes were assessed up to 10 years post-operatively.The results indicated that, irrespective of tibial fixation method, the overall survivorship was excellent at 99.6%.One knee in Group 2 with cementless fixation and screws required revision for aseptic loosening at 3 years, resulting in a cumulative survivorship of 88% at the end of 10 years.Functional outcomes showed no statistically significant differences between groups. Additionally, radiological outcomes,... Read More »
Level 1 RCT
3%
Synopsis: Two hundred and sixteen patients with advanced osteoarthritis scheduled for primary total knee arthroplasty (TKA) were randomized to receive one of three TKA prosthetic designs from the same system: cruciate-retaining (CR; n=72), anterior-stabilized (AS; n=72), or posterior-stabilized (PS; n=72).The primary outcome of interest was the mean score of all five subscales of the Knee injury and Osteoarthritis Outcome Score (KOOS) measured at a two-year follow-up appointment.Secondary outcomes included individual KOOS subscales, Oxford Knee Score, EuroQol five-dimension health questionnaire, EuroQol visual analogue scale, range of motion, and patient satisfaction.Outcomes were assessed up to two years postoperatively.Overall, patients reported similar levels of pain, function, satisfaction, and general health in all three prosthetic design groups. However, the PS... Read More »
Level 1 RCT
3%
Synopsis: Eight studies, including 615 patients who underwent total hip arthroplasty (THA), were analyzed in this systematic review and meta-analysis comparing the Direct Anterior Approach (DAA; n=303) to the Postero-Lateral Approach (PLA; n=312).Pooled outcomes of interest included surgical site infection rate, duration of the operation, length of incision, and pain scores using the visual analog scale (VAS) after surgery.The meta-analysis revealed no statistically significant difference in wound infections between DAA and PLA.However, DAA was associated with a shorter incision length, longer operative times, and lower postoperative pain VAS scores within 6 weeks. Additional research is... Read More »
Level 1 Meta Analysis
2%
Synopsis: 52 patients were randomized to receive one of two treatments for acute scaphoid fracture.One group underwent a surgical (internal fixation) procedure while the second group underwent a closed (cast treatment) procedure.The primary outcomes examined were total (indirect and direct) costs of either treatment as well as length of work absences.Results demonstrated that there was a higher total cost incurred from surgical treatment in both manual and non-manual workers. However, closed treatment... Read More »
Level 2 RCT
2%
Synopsis: 38 adolescents with 50 knees affected by Osgood-Schlatter disease were randomized to three monthly treatments of either prolotherapy with a dextrose solution, or so sham prolotherapy with saline.Patients were assessed for function on the Victorian Institute of Sport Assessment (VISA) score after 1, 2 and 3 months. Results demonstrated no... Read More »
Conference Report
2%
Synopsis: Three hundred and three patients with ankle osteoarthritis were randomized to receive either total ankle replacement (n=152) or ankle arthrodesis (n=151).The primary outcome of this trial was the change in the Manchester-Oxford Foot Questionnaire walking/standing (MOXFQ-W/S) from baseline to one year.Other outcomes of interest were MOXFQ-W/S, -pain and social interaction at 26 and 52 weeks, Foot and Ankle Ability Measure - activities of daily living (FAAM-ADL), and sport subscale scores at 26 and 52 weeks.Quality of life was also assessed using the EuroQoL 5-Dimension 5-Level questionnaire at 12, 26, and 52 weeks. Both groups saw... Read More »
Level 1 RCT
2%
Synopsis: Thirty randomized controlled trials with a total of 6650 patients who sustained hip fractures classified as AO/OTA31A1-A3 were included in this systematic review and meta-analysis comparing surgical fracture fixation with intramedullary nail (IMN) versus dynamic hip screw (DHS).Pooled outcomes of interest included intraoperative differences such as blood loss and screening time, postoperative differences including hospital stays, time to healing, Harris score as well as complications such as femoral neck shortening, non-union, and femoral fractures. The analysis revealed... Read More »
Level 1 Meta Analysis