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Muramyl tripeptide in chemotherapy improves overall osteosarcoma survival

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August 2013
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Muramyl tripeptide in chemotherapy improves overall osteosarcoma survival

Vol: 2| Issue: 7| Number:613| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival--a report from the Children's Oncology Group

J Clin Oncol. 2008 Feb 1;26(4):633-8. doi: 10.1200/JCO.2008.14.0095

Contributing Authors:
PA Meyers CL Schwartz MD Krailo JH Healey ML Bernstein D Betcher WS Ferguson MC Gebhardt AM Goorin M Harris E Kleinerman MP Link H Nadel M Nieder GP Siegal MA Weiner RJ Wells RB Womer HE Grier Children's Oncology Group

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Dr. Paul A. Meyers discusses the addition of muramyl tripeptide to chemotherapy in the treatment of Osteosarcoma.

Synopsis

662 osteosarcoma patients without detectable metastatic disease were either randomized to three drug (cisplatin, doxorubicin, methotrexate) or four drug chemotherapy (cisplatin, doxorubicin, methotrexate, and ifosfamide). A further comparison was conducted on the effects of the addition muramyl tri-peptide (MTP) to both chemotherapy regimens. Four- and six-year evaluations of event free survival (...

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