Tranexamic acid is effective in reducing blood loss, while maintaining safety, in THA

Arch Orthop Trauma Surg. 2013 Jul;133(7):1017-27. doi: 10.1007/s00402-013-1761-2. Epub 2013 Apr 25

AAOS 2016: Interim evaluation of tranexamic acid vs placebo in acetabular fracture surgery

Tranexamic acid reduces blood loss and transfusions in TKA and THA

BMC Res Notes. 2013 May 7;6:184. doi: 10.1186/1756-0500-6-184

AAOS2018: TXA effective in operative management for high-energy pelvic and femoral fractures

COA2017: IA TXA and IV TXA demonstrate similar results for blood loss in total hip arthroplasty

AAOS 2016: TXA vs. epsilon-aminocaproic acid provide comparable outcomes after TKA

Efficacy of various tranexamic acid administration techniques to reduce blood loss in TKA

Knee Surg Sports Traumatol Arthrosc. 2014 Dec;22(12):3181-90.

Intravenous TXA prior to tourniquet inflation more efficacious compared to later timepoints

J Arthroplasty. 2017 Jan;32(1):33-36

IV & topical TXA similarly safe & effective for reducing blood loss and transfusion in TKA

J Orthop. 2016 Mar 26;13(3):127-31

Lower blood loss with IV+IA TXA versus IV TXA alone following total knee arthroplasty

J Bone Joint Surg Am. 2016 May 18;98(10):835-41

AAOS2018: IV TXA reduced blood loss in total shoulder arthroplasty

Equivalent blood conservation with intra-articular and intravenous TXA in TKA

J Bone Joint Surg Am. 2014 Dec 3;96(23):1937-44

AAOS: Tranexamic acid equally effective when administered topically & intravenously in TKA

Similar effect of intra-articular vs IV TXA on Hb drop, LoS, and transfusion following TKA

J Arthroplasty. 2017 Jan;32(1):28-32

AAOS 2016: Intravenous and topical TXA yield similar efficacy and safety in THA

Blood loss and transfusion needs reduced with TXA in major orthopaedic surgery

J Surg Res. 2014 Jan;186(1):318-27. doi: 10.1016/j.jss.2013.08.020. Epub 2013 Sep 13

Similar efficacy with EACA and TXA for reduction of blood loss in patients undergoing TKA

J Orthop Traumatol. 2019 Jul 18;20(1):28.

IA-TXA effective compared to placebo for blood loss and transfusion reduction in TKA

J Knee Surg. 2018 Jan;31(1):56-67

Intracapsular and intravenous administration for TXA similar in efficacy and safety in TKA

J Arthroplasty. 2016 Nov;31(11):2452-2457

AAOS 2015: Tranexamic acid effectively lowers blood loss following TKA without tourniquet