Topical TXA found safe and effective for reduction of blood loss and transfusion in TKA

Orthopedics. 2015 May 1;38(5):315-24.

TXA efficacy in perioperative spinal surgery bleeding

Spine J. 2015 Apr 1;15(4):752-761.

Similar efficacy with EACA and TXA for reduction of blood loss in patients undergoing TKA

J Orthop Traumatol. 2019 Jul 18;20(1):28.

Non-inferior efficacy of topical TXA to IV TXA in total knee arthroplasty patients

J Arthroplasty. 2014 Aug;29(8):1528-31

Tranexamic acid reduces blood loss and transfusions in TKA and THA

BMC Res Notes. 2013 May 7;6:184. doi: 10.1186/1756-0500-6-184

Multi-dose oral TXA in total knee arthroplasty reduces blood loss with no increase in complication

Int J Surg. 2019 May;65:45-51.

COA/ICORS2019: Perioperative IA-IV TXA most effective regimen for reducing blood loss in TKA

Low- and high-dose TXA effective in reducing blood loss and transfusion needs in TKA

BMC Musculoskelet Disord. 2013 Dec 5;14:340. doi: 10.1186/1471-2474-14-340

IV and topical TXA superior to placebo for hematological outcomes after PLIF

World Neurosurg. 2019 Feb;122:e821-e827.

AAOS2019: Similar outcomes with oral and IV TXA for blood loss in thoracolumbar spinal fusion

AAOS 2016: TXA reduces total blood loss in extra-capsular hip fractures

IV & topical TXA similarly safe & effective for reducing blood loss and transfusion in TKA

J Orthop. 2016 Mar 26;13(3):127-31

ISAKOS2017: IA TXA reduces postoperative bleeding in anterior cruciate ligament reconstruction

TXA is effective and safe for reducing blood loss and transfusion in TKA patients

Eur J Orthop Surg Traumatol. 2015 Apr;25(3):525-41

AAOS 2015: Combined IV and local TXA administration efficacious in TKA

AAOS 2016: Oral and IV TXA demonstrate equivalent efficacy for blood loss in THA

Low-dose tranexamic acid does not reduce blood loss or transfusion rate in spinal surgery

J Neurosurg Anesthesiol. 2011 Oct;23(4):290-6. doi: 10.1097/ANA.0b013e31822914a1

TXA Reduces Blood Loss in Surgeries for Fractures of the Pelvis, Acetabulum and Proximal Femur

J Orthop Trauma. 2019 Aug;33(8):371-376.

Intravenous, intraarticular irrigation, and drain administration of TXA in TKA

J Arthroplasty. 2014 Aug;29(8):1521-4

AAOS 2016: Differences in blood loss noted with various TXA administration methods in TKA