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Autologous blood product injection no more effective than placebo saline for Achilles tendinopathy

Arthroscopy. 2018 Jun;34(6):1966-1975

Meta-analysis Foot & Ankle Athletes Lower Extremity Muscle Achilles Tendinopathy Autologous Blood Placebo Injection Placebo Saline Platelet-Rich Plasma - Hide

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Corticosteroid injection not effective in treatment of lateral epicondylalgia

JAMA. 2013 Feb 6;309(5):461-9. doi: 10.1001/jama.2013.129

RCT Shoulder & Elbow Upper Extremity Epicondyle Corticosteroid Injection Physiotherapy Single Injection - Hide

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OARSI 2016: Efficacy of intramuscular corticosteroid injection vs. placebo for hip OA

RCT Osteoarthritis Lower Extremity Hip Muscle Gluteus Arthritis Pain Stiffness Corticosteroid Injection IM Intramuscular Injection Placebo Injection - Hide

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Hylan injection no different than placebo injection for pain improvement in hip osteoarthritis

Osteoarthritis Cartilage. 2019 Jan;27(1):59-70. doi: 10.1016/j.joca.2018.08.018.

RCT Osteoarthritis Lower Extremity Hip Arthritis Pain Sanofi Hylan Placebo Saline Single Intraarticular Injection - Hide

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Dehydrated human amnion/chorion membrane (dHACM) injection vs. placebo for plantar fasciitis

Foot Ankle Int. 2018 Oct;39(10):1151-1161. doi: 10.1177/1071100718788549

RCT Foot & Ankle Lower Extremity Muscle Plantar Fascia Plantar Fasciitis MiMedx Injection Fascia Placebo Sodium Chloride - Hide

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Extended-release triamcinolone acetonide (FX006) versus placebo in knee osteoarthritis treatment

J Bone Joint Surg Am. 2018 Apr 18;100(8):666-677

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Flexion Therapeutics Extended-Release Placebo Single Injection Triamcinolone Acetonide - Hide

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Subacromial Corticosteroid Injection effective for patients with Hemiplegic Shoulder Pain

Arch Phys Med Rehabil. 2012 Jun;93(6):949-56. doi: 10.1016/j.apmr.2012.02.002. Epub 2012 Apr 5

RCT Shoulder & Elbow Upper Extremity Shoulder Bone Subacromial Muscle Rotator Cuff Pain Lidocaine Placebo Subacromial Corticosteroid Injection - Hide

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No difference in 1-wk pain and function improvement between steroid vs placebo injection for knee OA

Ann Rheum Dis. 2014 Aug;73(8):1590-1. doi: 10.1136/annrheumdis-2014-205206

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Methylprednisolone Intraarticular Injection Placebo Injection Ultrasound - Hide

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Better longer-term results with PRP versus CS and placebo injection for plantar fasciitis

J Foot Ankle Surg. 2019 Jan;58(1):42-46. doi: 10.1053/j.jfas.2018.07.006

RCT Foot & Ankle Lower Extremity Muscle Plantar Fascia Plantar Fasciitis Methylprednisolone Lidocaine Placebo Platelet Rich Plasma PRP Single Injection - Hide

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Botulinum toxin versus placebo injection for plantar fasciitis at 6 and 12 month follow-up

Foot Ankle Int. 2017 Jan;38(1):1-7

RCT Foot & Ankle Lower Extremity Muscle Plantar Fascia Plantar Fasciitis Injection Botulinum Toxin Flexor Placebo - Hide

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Comparing hydrocortisone acetate/t-butylacetate vs placebo injection for knee OA

Ann Rheum Dis. 1960 Sep;19:257-61

RCT Osteoarthritis Lower Extremity Knee Arthritis Acetate Injections Hydrocortisone Placebo Injection - Hide

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Hyaluronic acid injection similar in symptom & structure of knee OA vs diacerein & placebo

Ann Rheum Dis. 2004 Dec;63(12):1611-7

RCT Osteoarthritis Lower Extremity Knee Arthritis Roussel Diacerein Injections Hyaluronic Acid Oral Placebo Saline - Hide

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Hypertonic Dextrose Injection Improves Clinical Outcomes in Patients with Supraspinatus Tendinopathy

Eur J Phys Rehabil Med. 2019 Aug;55(4):480-487.

RCT Shoulder & Elbow Upper Extremity Shoulder Muscle Supraspinatus Supraspinatus Tendon Pain Tendinopathy Injection Dextrose Placebo Saline - Hide

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Significant 3-week pain reduction with methylprednisolone vs saline injection for knee OA

Ann Rheum Dis. 1996 Nov;55(11):829-32

RCT Osteoarthritis Lower Extremity Knee Muscle Quadricep Arthritis Pain Corticosteroid Injection Methylprednisolone Acetate Reduction Saline Injection - Hide

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No significant difference in effect on cartilage volume between HA vs placebo injection

Clin Exp Pharmacol 2012, 2:2

RCT Osteoarthritis Women Lower Extremity Knee Arthritis Cartilage Injections HA MRI Placebo Sodium Hyaluronate - Hide

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Both 2 and 3 Hylan injections more effective than placebo for knee OA

Current Therapeutic Research, March 1994 Volume 55, Issue 3, Pages 220–232

RCT Osteoarthritis Lower Extremity Knee Arthritis Biomatrix Hylan Hylan Injections Placebo - Hide

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AAOS 2016: High-dose hyaluronate reduces pain versus placebo for plantar fasciitis

RCT Foot & Ankle Lower Extremity Muscle Plantar Fascia Pain Plantar Fasciitis Injections High-Dose Hyaluronate Low-Dose Placebo - Hide

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Combined hyaluronic acid and corticosteroid injection reduces pain compared to placebo

Cartilage. 2017 May. doi: 10.1177/1947603517703732.

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Anika Monovisc Injection Corticosteroid Hyaluronic Acid Placebo Sodium Hyaluronate Triamcinolone Hexacetonide - Hide

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Multi-injection HA appears to be more effective than single-injection HA versus saline for knee OA

BMC Musculoskelet Disord. 2017 Dec 21;18(1):542

Meta-analysis Osteoarthritis Lower Extremity Knee Arthritis Ferring HA Hyaluronic Acid Injections Placebo Injection Placebo Saline Single Injection - Hide

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No difference in clinical efficacy between single NASHA and placebo injection for knee OA

Osteoarthritis Cartilage. 2004 Aug;12(8):642-9.

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Q-Med AB Durolane Injection NASHA Placebo Saline Sodium Chloride Stabilized Hyaluronic Acid - Hide

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Autologous blood product injection no more effective than placebo saline for Achilles tendinopathy

Corticosteroid injection not effective in treatment of lateral epicondylalgia

OARSI 2016: Efficacy of intramuscular corticosteroid injection vs. placebo for hip OA

Hylan injection no different than placebo injection for pain improvement in hip osteoarthritis

Dehydrated human amnion/chorion membrane (dHACM) injection vs. placebo for plantar fasciitis

Extended-release triamcinolone acetonide (FX006) versus placebo in knee osteoarthritis treatment

Subacromial Corticosteroid Injection effective for patients with Hemiplegic Shoulder Pain

No difference in 1-wk pain and function improvement between steroid vs placebo injection for knee OA

Better longer-term results with PRP versus CS and placebo injection for plantar fasciitis

Botulinum toxin versus placebo injection for plantar fasciitis at 6 and 12 month follow-up

Comparing hydrocortisone acetate/t-butylacetate vs placebo injection for knee OA

Hyaluronic acid injection similar in symptom & structure of knee OA vs diacerein & placebo

Hypertonic Dextrose Injection Improves Clinical Outcomes in Patients with Supraspinatus Tendinopathy

Significant 3-week pain reduction with methylprednisolone vs saline injection for knee OA

No significant difference in effect on cartilage volume between HA vs placebo injection

Both 2 and 3 Hylan injections more effective than placebo for knee OA

AAOS 2016: High-dose hyaluronate reduces pain versus placebo for plantar fasciitis

Combined hyaluronic acid and corticosteroid injection reduces pain compared to placebo

Multi-injection HA appears to be more effective than single-injection HA versus saline for knee OA

No difference in clinical efficacy between single NASHA and placebo injection for knee OA

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Emerging Treatments

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