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The efficacy & safety of various doses of fulranumab vs placebo for chronic LBP

Clin Ther. 2016 Jun;38(6):1435-50

RCT Spine Low Back Axial Skeleton Back Pain Amgen Injection Fulranumab Placebo - Hide

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Hyaluronic acid injection similar in symptom & structure of knee OA vs diacerein & placebo

Ann Rheum Dis. 2004 Dec;63(12):1611-7

RCT Osteoarthritis Lower Extremity Knee Arthritis Roussel Diacerein Injections Hyaluronic Acid Oral Placebo Saline - Hide

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OARSI 2016: Glucosamine and chondroitin not more effective than placebo for knee OA

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Chondroitin Sulfate Glucosamine Sulfate Oral Placebo - Hide

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Single-dose intra-articular bupivacaine significantly reduces pain after knee arthroscopy

Knee Surg Sports Traumatol Arthrosc. 2014 Jul;22(7):1517-28

Meta-analysis General Orthopaedics Lower Extremity Knee Pain Bupivacaine Analgesia Analgesic Arthroscopic Surgery Arthroscopy IA Placebo Reduction Single-Dose - Hide

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Glucosamine + chondroitin reduced joint space narrowing at 2 years vs. placebo in knee OA

Ann Rheum Dis. 2015 May;74(5):851-8.

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Aventis Sanofi Chondroitin Glucosamine Placebo - Hide

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Capsaicin provide comparable or better pain and functional improvement than placebo

Clin Drug Investig. 2011 Dec 1;31(12):877-82. doi: 10.2165/11593860-000000000-00000

RCT Arthroplasty Osteoarthritis Wound Lower Extremity Knee Arthritis Pain Anesiva Capsaicin Placebo - Hide

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Nabiximols improves multiple sclerosis spasticity compared to placebo over 12 weeks

Eur J Neurol. 2011 Sep;18(9):1122-31. doi: 10.1111/j.1468-1331.2010.03328.x

RCT Cannabis Placebo Pump Spray - Hide

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Delta-9 THC Improves Pain and Spasticity Compared to Placebo for Multiple Sclerosis Over 2 Weeks

CMAJ. 2012 Jul 10;184(10):1143-50. https://dx.doi.org/10.1503/cmaj.110837

RCT Cannabis Pain Placebo - Hide

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AAOS: Hyaluronic acid and placebo produce similar pain and functional outcomes for knee OA

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain HA Hyaluronic Acid Placebo Injections - Hide

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Dronabinol increases pain threshold compared to placebo for functional chest pain over 4 weeks

Dis Esophagus. 2017 Feb 1;30(2):1-8. doi: 10.1111/dote.12455

RCT Cannabis Pain Placebo - Hide

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AAOS 2016: High-dose hyaluronate reduces pain versus placebo for plantar fasciitis

RCT Foot & Ankle Lower Extremity Muscle Plantar Fascia Pain Plantar Fasciitis Injections High-Dose Hyaluronate Low-Dose Placebo - Hide

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Extended-release triamcinolone acetonide (FX006) versus placebo in knee osteoarthritis treatment

J Bone Joint Surg Am. 2018 Apr 18;100(8):666-677

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Flexion Therapeutics Extended-Release Placebo Single Injection Triamcinolone Acetonide - Hide

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Chrondroitin sulfate improves pain and function compared to placebo in the management of knee OA

Ann Rheum Dis. 2017 May 22. pii: annrheumdis-2016-210860. doi: 10.1136/annrheumdis-2016-210860. [Epub ahead of print]

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Innovative Neurotronics Institut Biochimique Pfizer Celecoxib Chondroitin Sulfate Placebo - Hide

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Rofecoxib and celecoxib demonstrate similar, significant 6-week efficacy vs placebo in OA treatment

Curr Med Res Opin. 2006 Jan;22(1):199-210

RCT Osteoarthritis Lower Extremity Knee Arthritis Merck Celecoxib Rofecoxib Placebo - Hide

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WCO-IOF: Dynamic electroneurostimulation vs placebo for osteoporotic spine fractures

RCT Spine Osteoporosis Postmenopausal Women Axial Skeleton Back Joint Vertebral Fracture Pain Dynamic Electroneurostimulation Placebo - Hide

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Celecoxib and naproxen beneficial in Asian patients with knee OA compared to a placebo

Int J Rheum Dis. 2016 Mar;19(3):262-70

RCT Osteoarthritis Lower Extremity Knee Arthritis Inflammation Pfizer Celecoxib Naproxen Nonsteroidal Placebo - Hide

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Vertebroplasty for osteoporotic fractures yield no benefit over placebo at 2-years

J Bone Miner Res. 2014 Jun;29(6):1346-55.

RCT Spine Osteoporosis Axial Skeleton Back Joint Vertebral Fracture Pain Placebo Vertebroplasty - Hide

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Oral tetrahydrocannabinol (THC) does not reduce chronic abdominal pain compared to placebo

Clin Gastroenterol Hepatol. 2017 Jul;15(7):1079-1086.e4. doi: 10.1016/j.cgh.2016.09.147

RCT Cannabis Muscle Abdominal Pain Placebo - Hide

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Either etodolac 400mg bid or naproxen 500mg bid effective versus placebo in knee OA treatment

Clin Ther. 1995 Jul-Aug;17(4):656-66

RCT Osteoarthritis Lower Extremity Knee Arthritis Naproxen Etodolac Placebo - Hide

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WCO-IOF 2016: Lasofoxifene, raloxifene, and placebo for BMD in postmenopausal women

RCT Metabolic Disorders Postmenopausal Women Axial Skeleton Spine Spine Lumbar Raloxifene Lasofoxifene Placebo - Hide

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The efficacy & safety of various doses of fulranumab vs placebo for chronic LBP

Hyaluronic acid injection similar in symptom & structure of knee OA vs diacerein & placebo

OARSI 2016: Glucosamine and chondroitin not more effective than placebo for knee OA

Single-dose intra-articular bupivacaine significantly reduces pain after knee arthroscopy

Glucosamine + chondroitin reduced joint space narrowing at 2 years vs. placebo in knee OA

Capsaicin provide comparable or better pain and functional improvement than placebo

Nabiximols improves multiple sclerosis spasticity compared to placebo over 12 weeks

Delta-9 THC Improves Pain and Spasticity Compared to Placebo for Multiple Sclerosis Over 2 Weeks

AAOS: Hyaluronic acid and placebo produce similar pain and functional outcomes for knee OA

Dronabinol increases pain threshold compared to placebo for functional chest pain over 4 weeks

AAOS 2016: High-dose hyaluronate reduces pain versus placebo for plantar fasciitis

Extended-release triamcinolone acetonide (FX006) versus placebo in knee osteoarthritis treatment

Chrondroitin sulfate improves pain and function compared to placebo in the management of knee OA

Rofecoxib and celecoxib demonstrate similar, significant 6-week efficacy vs placebo in OA treatment

WCO-IOF: Dynamic electroneurostimulation vs placebo for osteoporotic spine fractures

Celecoxib and naproxen beneficial in Asian patients with knee OA compared to a placebo

Vertebroplasty for osteoporotic fractures yield no benefit over placebo at 2-years

Oral tetrahydrocannabinol (THC) does not reduce chronic abdominal pain compared to placebo

Either etodolac 400mg bid or naproxen 500mg bid effective versus placebo in knee OA treatment

WCO-IOF 2016: Lasofoxifene, raloxifene, and placebo for BMD in postmenopausal women

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Emerging Treatments

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Evidence Series

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