The efficacy & safety of various doses of fulranumab vs placebo for chronic LBP

Clin Ther. 2016 Jun;38(6):1435-50

Hyaluronic acid injection similar in symptom & structure of knee OA vs diacerein & placebo

Ann Rheum Dis. 2004 Dec;63(12):1611-7

Glucosamine + chondroitin reduced joint space narrowing at 2 years vs. placebo in knee OA

Ann Rheum Dis. 2015 May;74(5):851-8.

Delta-9 THC Improves Pain and Spasticity Compared to Placebo for Multiple Sclerosis Over 2 Weeks

CMAJ. 2012 Jul 10;184(10):1143-50. https://dx.doi.org/10.1503/cmaj.110837

Chrondroitin sulfate improves pain and function compared to placebo in the management of knee OA

Ann Rheum Dis. 2017 May 22. pii: annrheumdis-2016-210860. doi: 10.1136/annrheumdis-2016-210860. [Epub ahead of print]

Single-dose intra-articular bupivacaine significantly reduces pain after knee arthroscopy

Knee Surg Sports Traumatol Arthrosc. 2014 Jul;22(7):1517-28

Dronabinol increases pain threshold compared to placebo for functional chest pain over 4 weeks

Dis Esophagus. 2017 Feb 1;30(2):1-8. doi: 10.1111/dote.12455

OARSI 2016: Glucosamine and chondroitin not more effective than placebo for knee OA

AAOS: Hyaluronic acid and placebo produce similar pain and functional outcomes for knee OA

Nabiximols improves multiple sclerosis spasticity compared to placebo over 12 weeks

Eur J Neurol. 2011 Sep;18(9):1122-31. doi: 10.1111/j.1468-1331.2010.03328.x

Titrated THC:CBD Improves Pain and Spasticity Compared to Placebo Over 12 Weeks for Resistant MS

Int J Neurosci. 2018 Sep 13:1-10.

Capsaicin provide comparable or better pain and functional improvement than placebo

Clin Drug Investig. 2011 Dec 1;31(12):877-82. doi: 10.2165/11593860-000000000-00000

Rofecoxib and celecoxib demonstrate similar, significant 6-week efficacy vs placebo in OA treatment

Curr Med Res Opin. 2006 Jan;22(1):199-210

WCO-IOF 2016: Lasofoxifene, raloxifene, and placebo for BMD in postmenopausal women

Either etodolac 400mg bid or naproxen 500mg bid effective versus placebo in knee OA treatment

Clin Ther. 1995 Jul-Aug;17(4):656-66

AAOS 2016: High-dose hyaluronate reduces pain versus placebo for plantar fasciitis

Vertebroplasty for osteoporotic fractures yield no benefit over placebo at 2-years

J Bone Miner Res. 2014 Jun;29(6):1346-55.

Diclofenac versus acetaminophen versus placebo for treatment of symptomatic knee osteoarthritis

Arch Intern Med. 2003 Jan 27;163(2):169-78

Delta 9-THC has better analgesic efficacy versus placebo for neuropathic pain over 6 hours

J Pain. 2008 Jun;9(6):506-21. doi: 10.1016/j.jpain.2007.12.010

Comparable efficacy with etoricoxib 30mg and ibuprofen 2400mg in treating hip or knee OA

Osteoarthritis Cartilage. 2007 Dec;15(12):1348-56. Epub 2007 Jul 16