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Hyaluronic acid injection similar in symptom & structure of knee OA vs diacerein & placebo

Ann Rheum Dis. 2004 Dec;63(12):1611-7

RCT Osteoarthritis Lower Extremity Knee Arthritis Roussel Diacerein Injections Hyaluronic Acid Oral Placebo Saline - Hide

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The efficacy & safety of various doses of fulranumab vs placebo for chronic LBP

Clin Ther. 2016 Jun;38(6):1435-50

RCT Spine Low Back Axial Skeleton Back Pain Amgen Injection Fulranumab Placebo - Hide

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Glucosamine + chondroitin reduced joint space narrowing at 2 years vs. placebo in knee OA

Ann Rheum Dis. 2015 May;74(5):851-8.

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Aventis Sanofi Chondroitin Glucosamine Placebo - Hide

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OARSI 2016: Glucosamine and chondroitin not more effective than placebo for knee OA

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Chondroitin Sulfate Glucosamine Sulfate Oral Placebo - Hide

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Single-dose intra-articular bupivacaine significantly reduces pain after knee arthroscopy

Knee Surg Sports Traumatol Arthrosc. 2014 Jul;22(7):1517-28

Meta-analysis General Orthopaedics Lower Extremity Knee Pain Bupivacaine Analgesia Analgesic Arthroscopic Surgery Arthroscopy IA Placebo Reduction Single-Dose - Hide

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Capsaicin provide comparable or better pain and functional improvement than placebo

Clin Drug Investig. 2011 Dec 1;31(12):877-82. doi: 10.2165/11593860-000000000-00000

RCT Arthroplasty Osteoarthritis Wound Lower Extremity Knee Arthritis Pain Anesiva Capsaicin Placebo - Hide

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AAOS: Hyaluronic acid and placebo produce similar pain and functional outcomes for knee OA

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain HA Hyaluronic Acid Placebo Injections - Hide

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Dronabinol increases pain threshold compared to placebo for functional chest pain over 4 weeks

Dis Esophagus. 2017 Feb 1;30(2):1-8. doi: 10.1111/dote.12455

RCT Cannabis Pain Placebo - Hide

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Delta-9 THC Improves Pain and Spasticity Compared to Placebo for Multiple Sclerosis Over 2 Weeks

CMAJ. 2012 Jul 10;184(10):1143-50. https://dx.doi.org/10.1503/cmaj.110837

RCT Cannabis Pain Placebo - Hide

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Chrondroitin sulfate improves pain and function compared to placebo in the management of knee OA

Ann Rheum Dis. 2017 May 22. pii: annrheumdis-2016-210860. doi: 10.1136/annrheumdis-2016-210860. [Epub ahead of print]

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Innovative Neurotronics Institut Biochimique Pfizer Celecoxib Chondroitin Sulfate Placebo - Hide

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AAOS 2016: High-dose hyaluronate reduces pain versus placebo for plantar fasciitis

RCT Foot & Ankle Lower Extremity Muscle Plantar Fascia Pain Plantar Fasciitis Injections High-Dose Hyaluronate Low-Dose Placebo - Hide

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WCO-IOF: Dynamic electroneurostimulation vs placebo for osteoporotic spine fractures

RCT Spine Osteoporosis Postmenopausal Women Axial Skeleton Back Joint Vertebral Fracture Pain Dynamic Electroneurostimulation Placebo - Hide

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Vertebroplasty for osteoporotic fractures yield no benefit over placebo at 2-years

J Bone Miner Res. 2014 Jun;29(6):1346-55.

RCT Spine Osteoporosis Axial Skeleton Back Joint Vertebral Fracture Pain Placebo Vertebroplasty - Hide

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WCO-IOF 2016: Lasofoxifene, raloxifene, and placebo for BMD in postmenopausal women

RCT Metabolic Disorders Postmenopausal Women Axial Skeleton Spine Spine Lumbar Raloxifene Lasofoxifene Placebo - Hide

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Nabiximols improves multiple sclerosis spasticity compared to placebo over 12 weeks

Eur J Neurol. 2011 Sep;18(9):1122-31. doi: 10.1111/j.1468-1331.2010.03328.x

RCT Cannabis Placebo Pump Spray - Hide

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Celecoxib and naproxen beneficial in Asian patients with knee OA compared to a placebo

Int J Rheum Dis. 2016 Mar;19(3):262-70

RCT Osteoarthritis Lower Extremity Knee Arthritis Inflammation Pfizer Celecoxib Naproxen Nonsteroidal Placebo - Hide

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Comparable efficacy with etoricoxib 30mg and ibuprofen 2400mg in treating hip or knee OA

Osteoarthritis Cartilage. 2007 Dec;15(12):1348-56. Epub 2007 Jul 16

RCT General Orthopaedics Osteoarthritis Lower Extremity Hip Knee Arthritis Merck Ibuprofen Etoricoxib Placebo - Hide

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Titrated THC:CBD Improves Pain and Spasticity Compared to Placebo Over 12 Weeks for Resistant MS

Int J Neurosci. 2018 Sep 13:1-10.

RCT Cannabis Pain Placebo Spray Cannabidiol - Hide

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Oral tetrahydrocannabinol (THC) does not reduce chronic abdominal pain compared to placebo

Clin Gastroenterol Hepatol. 2017 Jul;15(7):1079-1086.e4. doi: 10.1016/j.cgh.2016.09.147

RCT Cannabis Muscle Abdominal Pain Placebo - Hide

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Diclofenac versus acetaminophen versus placebo for treatment of symptomatic knee osteoarthritis

Arch Intern Med. 2003 Jan 27;163(2):169-78

RCT Osteoarthritis Lower Extremity Knee Arthritis Acetaminophen Diclofenac Sodium Placebo - Hide

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Hyaluronic acid injection similar in symptom & structure of knee OA vs diacerein & placebo

The efficacy & safety of various doses of fulranumab vs placebo for chronic LBP

Glucosamine + chondroitin reduced joint space narrowing at 2 years vs. placebo in knee OA

OARSI 2016: Glucosamine and chondroitin not more effective than placebo for knee OA

Single-dose intra-articular bupivacaine significantly reduces pain after knee arthroscopy

Capsaicin provide comparable or better pain and functional improvement than placebo

AAOS: Hyaluronic acid and placebo produce similar pain and functional outcomes for knee OA

Dronabinol increases pain threshold compared to placebo for functional chest pain over 4 weeks

Delta-9 THC Improves Pain and Spasticity Compared to Placebo for Multiple Sclerosis Over 2 Weeks

Chrondroitin sulfate improves pain and function compared to placebo in the management of knee OA

AAOS 2016: High-dose hyaluronate reduces pain versus placebo for plantar fasciitis

WCO-IOF: Dynamic electroneurostimulation vs placebo for osteoporotic spine fractures

Vertebroplasty for osteoporotic fractures yield no benefit over placebo at 2-years

WCO-IOF 2016: Lasofoxifene, raloxifene, and placebo for BMD in postmenopausal women

Nabiximols improves multiple sclerosis spasticity compared to placebo over 12 weeks

Celecoxib and naproxen beneficial in Asian patients with knee OA compared to a placebo

Comparable efficacy with etoricoxib 30mg and ibuprofen 2400mg in treating hip or knee OA

Titrated THC:CBD Improves Pain and Spasticity Compared to Placebo Over 12 Weeks for Resistant MS

Oral tetrahydrocannabinol (THC) does not reduce chronic abdominal pain compared to placebo

Diclofenac versus acetaminophen versus placebo for treatment of symptomatic knee osteoarthritis

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