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Higher efficacy and safety of 100 mg BID oral celecoxib in the treatment of knee or hip OA

Sci Rep. 2015 May 27;5:10593

Meta-analysis Osteoarthritis Lower Extremity Hip Knee Arthritis Oral Celecoxib Placebo - Hide

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Oral dronabinol and smoked cannabis have similar psychoactive effects, but peak at different times

Clin J Pain. 2014 Jun;30(6):472-8. doi: 10.1097/AJP.0000000000000022

RCT Cannabis Pain Solvay Solvay Pharmaceuticals - Hide

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THA: No benefit of high-volume ropivacaine infiltration to multimodal oral analgesia

Acta Orthop. 2011 Aug;82(4):423-6. Epub 2011 Jul 13

RCT Arthroplasty Lower Extremity Hip Ropivacaine Celecoxib Morphine Gabapentin Analgesia Bilateral High-Volume Infiltration Multimodal Oral Placebo Saline THA - Hide

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Topical drug-free therapy more effective than oral NSAID ketoprofen for muscle soreness

J Sports Sci. 2016 Jan;34(1):88-95.

RCT Sports Medicine Pain IDEA AG Drug-Free Exercise Gel NSAID Oral Topical Ketoprofen Transfersome - Hide

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Oral/parenteral vitamin D improves pain, mobility quality of life in elderly

Rheumatol Int. 2012 Aug;32(8):2279-83. doi: 10.1007/s00296-011-1943-6. Epub 2011 May 10.

RCT General Orthopaedics Community-Dwelling Elderly Pain Intramuscular Placebo Intramuscular Vitamin Mobility Oral - Hide

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Neither additional IV nor oral acetaminophen enhances multimodal analgesia efficacy in TKA

J Arthroplasty. 2017 Oct;32(10):3029-3033

RCT Arthroplasty Lower Extremity Knee Hydromorphone Care Intravenous Acetaminophen IV Multimodal Analgesia Oral Acetaminophen Oral Placebo - Hide

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Oral non-steroidal anti-inflammatory drugs: viable for pain relief of RC tendinopathy

J Rehabil Med. 2014 Mar 31;46(4):294-306. doi: 10.2340/16501977-1800.

Meta-analysis Shoulder & Elbow Upper Extremity Muscle Rotator Cuff Inflammation Pain Tendinopathy Control Oral Nsaids Placebo - Hide

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Preop oral TXA demonstrates noninferiority to IV TXA in TKA for hemostasis

J Arthroplasty. 2016 Sep;31(9 Suppl):26-30

RCT Arthroplasty Lower Extremity Knee Intravenous Tranexamic Acid IV TXA Oral TXA - Hide

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Modestly improved function with oral steroids for sciatica due to a herniated lumbar disk

JAMA. 2015 May 19;313(19):1915-23.

RCT Spine Discs Hernia Nerve Sciatica Lumbar Lower Extremity Knee Pain Radiculopathy Prednisone Oral Placebo - Hide

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AAOS2017: Similar Hb drop and transfusion rate between oral and IV TXA in THA

RCT Arthroplasty Lower Extremity Hip Intravenous Tranexamic Acid IV TXA Oral Replacement - Hide

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Undenatured type II collagen supplementation for symptomatic management of knee OA

Nutr J. 2016 Jan 29;15(1):14

RCT Osteoarthritis Lower Extremity Knee Arthritis InterHealth Collagen Glucosamine Hydrochloride Oral Supplementation Placebo Sulfate - Hide

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Hyaluronic acid injection similar in symptom & structure of knee OA vs diacerein & placebo

Ann Rheum Dis. 2004 Dec;63(12):1611-7

RCT Osteoarthritis Lower Extremity Knee Arthritis Roussel Diacerein Injections Hyaluronic Acid Oral Placebo Saline - Hide

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Assessing the efficacy of topical ketoprofen versus active- and placebo-comparators for knee OA

Rheumatology (Oxford). 2013 Jul;52(7):1303-12

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain IDEA AG Gel Oral Celecoxib Placebo Topical Ketoprofen Transfersome Vehicle - Hide

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Postoperative multi-dose oral versus IV TXA in total knee arthroplasty without tourniquet control

Thromb Res. 2018 Nov;171:68-73. doi: 10.1016/j.thromres.2018.09.054

RCT General Orthopaedics Osteoarthritis Lower Extremity Knee Arthritis Arthroplasty Blood Loss Intravenous Tranexamic Acid IV TXA Oral Tranexamic Acid Tourniquet - Hide

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OARSI 2016: Glucosamine and chondroitin not more effective than placebo for knee OA

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Chondroitin Sulfate Glucosamine Sulfate Oral Placebo - Hide

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Oral tetrahydrocannabinol (THC) does not reduce chronic abdominal pain compared to placebo

Clin Gastroenterol Hepatol. 2017 Jul;15(7):1079-1086.e4. doi: 10.1016/j.cgh.2016.09.147

RCT Cannabis Muscle Abdominal Pain Placebo - Hide

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Oral administration of salmon calcitonin for postmenopausal women with low bone mass

Osteoporos Int. 2014 Nov;25(11):2649-56

RCT General Orthopaedics Postmenopausal Women Fracture Tarsa Therapeutics Instructed Oral Placebo Salmon Calcitonin - Hide

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Supplementation with Boswellia serrata extract versus placebo for knee osteoarthritis treatment

Phytother Res. 2019 May;33(5):1457-1468. doi: 10.1002/ptr.6338

RCT Osteoarthritis Lower Extremity Knee Arthritis Inflammation Extract Oral Placebo - Hide

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AAOS 2023: Oral Dexamethasone for Pain Control After Total Knee Arthroplasty

RCT Arthroplasty Lower Extremity Knee Pain Dexamethasone Control Oral Placebo - Hide

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Oral alendronate cannot yet be recommended for children with OI

J Clin Endocrinol Metab. 2011 Feb;96(2):355-64

RCT Pediatric Orthopaedics Adolescent Children Osteogenesis Merck Oral Alendronate Placebo - Hide

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Higher efficacy and safety of 100 mg BID oral celecoxib in the treatment of knee or hip OA

Oral dronabinol and smoked cannabis have similar psychoactive effects, but peak at different times

THA: No benefit of high-volume ropivacaine infiltration to multimodal oral analgesia

Topical drug-free therapy more effective than oral NSAID ketoprofen for muscle soreness

Oral/parenteral vitamin D improves pain, mobility quality of life in elderly

Neither additional IV nor oral acetaminophen enhances multimodal analgesia efficacy in TKA

Oral non-steroidal anti-inflammatory drugs: viable for pain relief of RC tendinopathy

Preop oral TXA demonstrates noninferiority to IV TXA in TKA for hemostasis

Modestly improved function with oral steroids for sciatica due to a herniated lumbar disk

AAOS2017: Similar Hb drop and transfusion rate between oral and IV TXA in THA

Undenatured type II collagen supplementation for symptomatic management of knee OA

Hyaluronic acid injection similar in symptom & structure of knee OA vs diacerein & placebo

Assessing the efficacy of topical ketoprofen versus active- and placebo-comparators for knee OA

Postoperative multi-dose oral versus IV TXA in total knee arthroplasty without tourniquet control

OARSI 2016: Glucosamine and chondroitin not more effective than placebo for knee OA

Oral tetrahydrocannabinol (THC) does not reduce chronic abdominal pain compared to placebo

Oral administration of salmon calcitonin for postmenopausal women with low bone mass

Supplementation with Boswellia serrata extract versus placebo for knee osteoarthritis treatment

AAOS 2023: Oral Dexamethasone for Pain Control After Total Knee Arthroplasty

Oral alendronate cannot yet be recommended for children with OI

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