Tranexamic Acid Reduces Blood Loss and Blood Transfusion after TKA

Clin Orthop Relat Res. 2011 Oct;469(10):2874-80. Epub 2011 Apr 22

AAOS 2015: No difference between topical and intravenous tranexamic acid for TKA

Intracapsular and intravenous administration for TXA similar in efficacy and safety in TKA

J Arthroplasty. 2016 Nov;31(11):2452-2457

Equivalent blood conservation with intra-articular and intravenous TXA in TKA

J Bone Joint Surg Am. 2014 Dec 3;96(23):1937-44

Similar effect of intra-articular vs IV TXA on Hb drop, LoS, and transfusion following TKA

J Arthroplasty. 2017 Jan;32(1):28-32

AAOS2017: Blood loss and transfusion rate similar with intravenous and topical TXA in THA

AAOS2018: IV TXA reduced blood loss in total shoulder arthroplasty

IV tranexamic acid reduces blood loss and transfusion rate in primary THA

Orthopedics. 2016 Sep 1;39(5):e883-92

Combination of intravenous and topical TXA improves outcomes following primary TKA

J Arthroplasty. 2014 Dec;29(12):2342-6.

Lower blood loss with IV+IA TXA versus IV TXA alone following total knee arthroplasty

J Bone Joint Surg Am. 2016 May 18;98(10):835-41

AAOS 2015: No difference between intra-articular & intravenous TXA administration in TKA

TKA: Topical Fibrin Spray and Tranexamic acid reduce blood loss

J Bone Joint Surg Br. 2007 Mar;89(3):306-9

COA2017: IA TXA and IV TXA demonstrate similar results for blood loss in total hip arthroplasty

Intravenous TXA prior to tourniquet inflation more efficacious compared to later timepoints

J Arthroplasty. 2017 Jan;32(1):33-36

Tranexamic acid efficacious in reducing blood loss and transfusion in bilateral TKA

J Arthroplasty. 2016 Nov;31(11):2471-2475

Efficacy of various tranexamic acid administration techniques to reduce blood loss in TKA

Knee Surg Sports Traumatol Arthrosc. 2014 Dec;22(12):3181-90.

AAOS 2016: Intravenous and topical TXA yield similar efficacy and safety in THA

AAOS2018: TXA effective in operative management for high-energy pelvic and femoral fractures

3 doses of tranexamic acid more effective regimen in TKA

Clin Orthop Relat Res. 2012 Sep;470(9):2605-12. doi: 10.1007/s11999-012-2310-y. Epub 2012 Mar 15.

Combined IV-topical TXA more effective than IV TXA alone in total hip and knee arthroplasty

Int J Surg. 2016 Dec;36(Pt A):324-329