Non-inferior efficacy of topical TXA to IV TXA in total knee arthroplasty patients

J Arthroplasty. 2014 Aug;29(8):1528-31

Combination of intravenous and topical TXA improves outcomes following primary TKA

J Arthroplasty. 2014 Dec;29(12):2342-6.

COA/ICORS2019: Perioperative IA-IV TXA most effective regimen for reducing blood loss in TKA

Similar blood loss and lower cost with oral TXA vs. both IA TXA and IV TXA in total hip arthroplasty

J Arthroplasty. 2018 Mar;33(3):786-793

AAOS 2016: IV+IA TXA significantly reduces blood loss compared to IV TXA alone in TKA

Intracapsular and intravenous administration for TXA similar in efficacy and safety in TKA

J Arthroplasty. 2016 Nov;31(11):2452-2457

Large-scale trial comparing topical and intravenous TXA efficacy in total knee arthroplasty

J Bone Joint Surg Am. 2018 Jun 20;100(12):1023-1029

IV & topical TXA similarly safe & effective for reducing blood loss and transfusion in TKA

J Orthop. 2016 Mar 26;13(3):127-31

AAOS 2016: Oral and IV TXA demonstrate equivalent efficacy for blood loss in THA

COA/ICORS2019: Blood loss, Hb drop, and transfusion rate similar between IA TXA and IV TXA in TKA

AAOS 2015: No difference between intra-articular & intravenous TXA administration in TKA

Lower blood loss with IV+IA TXA versus IV TXA alone following total knee arthroplasty

J Bone Joint Surg Am. 2016 May 18;98(10):835-41

Combined IV-topical TXA versus IV TXA alone in patients undergoing revision THA

J Arthroplasty. 2016 Nov;31(11):2548-2553

Combined IV-IA TXA further reduces blood loss versus IV TXA alone, but does not reduce transfusion

BMC Musculoskelet Disord. 2018 Sep 7;19(1):321. doi: 10.1186/s12891-018-2181-9

AAOS2017: Blood loss and transfusion rate similar with intravenous and topical TXA in THA

Topical and intravenous tranexamic acid equally effective in total knee arthroplasty

Knee. 2014 Dec;21(6):987-993

TXA effective in reducing blood loss and transfusion in TKA vs. routine hemostasis

Arch Orthop Trauma Surg. 2015 Jul;135(7):1017-25

AAOS 2016: Differences in blood loss noted with various TXA administration methods in TKA

AAOS2018: IV-TXA reduces blood loss, not transfusion rate, in reverse total shoulder arthroplasty

Periarticular and intravenous TXA comparable in blood loss and transfusion rates after TKA

BMC Musculoskelet Disord. 2016 Jul 26;17:313.