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Periarticular multimodal drug injections effective and safe analgesic for TKA

Knee Surg Sports Traumatol Arthrosc. 2014 Aug;22(8):1949-57. doi: 10.1007/s00167-013-2566-0. Epub 2013 Jun 20.

Meta-analysis Arthroplasty Lower Extremity Knee Epinephrine Anaesthesia Analgesic Injections Corticosteroid Local Infiltration Periarticular Multimodal Placebo Replacement TKA - Hide

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Only analgesic difference between early vs late intraoperative periarticular injection found in PACU

Knee Surg Sports Traumatol Arthrosc. 2019 Apr;27(4):1124-1131. doi: 10.1007/s00167-018-5140-y

RCT Arthroplasty Lower Extremity Knee Pain Biomet Ropivacaine Methylprednisolone Epinephrine Ketoprofen Morphine Hydrochloride Band Cementation Extensor Fascial Implant PAI Periarticular Injection PES Saline - Hide

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TKA: Postoperative opiate use lowered by intraoperative periarticular LIA

Acta Orthop. 2014 Dec;85(6):614-9.

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Levobupivacaine Ketorolac Oxycodone Adrenaline LIA Periarticular Local Infiltration Analgesia Placebo Saline - Hide

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Periarticular injection for pain relief and early knee flexion angle after TKA

J Bone Joint Surg Am. 2014 Sep 3;96(17):1433-8

RCT General Orthopaedics Axial Skeleton Spine Lower Extremity Knee Pain Ropivacaine Bupivacaine Diclofenac Anaesthesia Arthroplasty Epidural Analgesia Morphine Hydrochloride Hydrate Opioid Periarticular Injection Spinal Anesthesia - Hide

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Early benefit with periarticular analgesia for pain relief in simultaneous bilateral TKA

J Bone Joint Surg Am. 2015 Mar 4;97(5):367-73

RCT Arthroplasty Lower Extremity Knee Pain Stryker Ropivacaine Diclofenac Bilateral Epidural Analgesia Periarticular Injection - Hide

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TKA: Intraoperative corticosteroid injections reduce hospital stay length

J Bone Joint Surg Am. 2009 Nov;91(11):2550-5.

RCT Arthroplasty Lower Extremity Knee Cefuroxime Epinephrine Morphine Clonidine Corticosteroid Injections Bupivacaine Hydrochloride Periarticular Injection Saline Solution Steroid - Hide

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AAOS 2016: No added benefit of morphine to periarticular injection for TKA

RCT Arthroplasty Lower Extremity Knee Ropivacaine Methylprednisolone Epinephrine Morphine Bilateral Periarticular Injection - Hide

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Fascia iliaca block offers opioid sparing effect vs PAI in patients undergoing TKA

J Clin Anesth. 2016 Dec;35:404-410

RCT Arthroplasty Lower Extremity Knee Bupivacaine Morphine Analgesic Fascia Iliaca Block Periarticular Injection Analgesia - Hide

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TKA: Addition of steroid to periarticular injection may reduce postoperative pain

Yonsei Med J. 2014 Mar;55(2):493-8

RCT Arthroplasty Women Lower Extremity Knee Pain DePuy Johnson & Johnson Sigma Ropivacaine Celecoxib Epinephrine Ketorolac Pregabalin Implant Non-Steroid Periarticular Injection Prosthesis Standard Medial Parapatellar Arthrotomy TKA Tourniquet - Hide

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TKA analgesic: Periarticular injection with steroids superior to those without steroids

Chin Med J (Engl). 2013 Oct;126(20):3851-5

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Celecoxib Morphine Analgesic Multimodal Periarticular Injection Standard Medial Parapatellar Arthrotomy Steroid TKA - Hide

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COA 2016: Motor sparing knee block versus periarticular infiltration for pain after TKA

RCT Arthroplasty Nerve Lower Extremity Knee Bone Femur Muscle Adductor Quadricep Pain Ropivacaine Epinephrine Morphine Ketorolac Analgesia Injection Block Canal Cutaneous Intraoperative Periarticular Infiltration PAI Preoperative TKA - Hide

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Influences of route of acetaminophen administration and periarticular liposomal bupivacaine in TKA

J Arthroplasty. 2018 Jul;33(7S):S136-S141. doi: 10.1016/j.arth.2018.02.088

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Pain Lidocaine Epinephrine Morphine Ketorolac Acetaminophen Analgesic Regimen Bupivacaine Hydrochloride Intraoperative Periarticular Infiltration Liposomal Bupivacaine Saline - Hide

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Periarticular multimodal drug injection safe and efficacious alternative to FNB in TKA

J Arthroplasty. 2015 Jul;30(7):1281-6.

Meta-analysis Arthroplasty Nerve Lower Extremity Knee Bone Femur Pain Analgesia Femoral Nerve Block FNB Local Infiltration Periarticular Injection Periarticular Multimodal Replacement TKA - Hide

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Periarticular injections vs. no injection for analgesia after high tibial osteotomy

Arthroscopy. 2014 Oct;30(10):1261-8

RCT General Orthopaedics Bone Tibia 3M Synthes Bupivacaine Fentanyl Injections Medial Opening-Wedge Opening-Wedge High Tibial Osteotomy Periarticular Multimodal - Hide

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Similar efficacy between intra- and periarticular injections for acromioclavicular joint

Arthroscopy. 2013 Dec;29(12):1903-10. doi: 10.1016/j.arthro.2013.08.027. Epub 2013 Oct 18

RCT Shoulder & Elbow Upper Extremity Shoulder Joint Acromioclavicular Pain Gebro Pharma Merck Betamethasone Periarticular Injection Ultrasound-Guided Injection Of Lidocaine Hydrochloride - Hide

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AAOS 2016: Femoral nerve block vs. periarticular injection in total knee arthroplasty

RCT Arthroplasty Nerve Lower Extremity Knee Bone Femur Ropivacaine Epinephrine Morphine Ketorolac Analgesia CFNB Femoral Nerve Block Catheter Periarticular Injection - Hide

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Periarticular analgesic cocktail injection effective in reducing pain after TKA

J Arthroplasty. 2010 Sep;25(6):851-7

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Pain Methylprednisolone Fentanyl Analgesic Injections Injection Of Bupivacaine Periarticular Injection - Hide

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AAOS2017: Analgesic efficacy of motor-sparing block vs. periarticular injection in TKA

RCT Arthroplasty Lower Extremity Knee Bone Femur Muscle Adductor Ropivacaine Epinephrine Morphine Ketorolac Analgesia Canal Cutaneous Motor-Sparing Block PAI Periarticular Injection Ultrasound - Hide

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Steroid addition to multimodal cocktail periarticular injection safe and effective in TKA

J Orthop Surg Res. 2015 May 22;10(1):75

Meta-analysis Arthroplasty Lower Extremity Knee Glucocorticoid Drainage Multimodal Periarticular Injection ROM Steroid Unilateral TKA - Hide

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Lumbar plexus block vs periarticular infiltration with ropivacaine or liposomal bupivacaine in THA

J Bone Joint Surg Am. 2017 Nov 1;99(21):1836-1845

RCT Arthroplasty Nerve Spine Lumbar Lower Extremity Hip Ropivacaine Epinephrine Morphine Liposomal Bupivacaine Nerve Block PAI-R Periarticular Infiltration Plexus Block - Hide

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Periarticular multimodal drug injections effective and safe analgesic for TKA

Only analgesic difference between early vs late intraoperative periarticular injection found in PACU

TKA: Postoperative opiate use lowered by intraoperative periarticular LIA

Periarticular injection for pain relief and early knee flexion angle after TKA

Early benefit with periarticular analgesia for pain relief in simultaneous bilateral TKA

TKA: Intraoperative corticosteroid injections reduce hospital stay length

AAOS 2016: No added benefit of morphine to periarticular injection for TKA

Fascia iliaca block offers opioid sparing effect vs PAI in patients undergoing TKA

TKA: Addition of steroid to periarticular injection may reduce postoperative pain

TKA analgesic: Periarticular injection with steroids superior to those without steroids

COA 2016: Motor sparing knee block versus periarticular infiltration for pain after TKA

Influences of route of acetaminophen administration and periarticular liposomal bupivacaine in TKA

Periarticular multimodal drug injection safe and efficacious alternative to FNB in TKA

Periarticular injections vs. no injection for analgesia after high tibial osteotomy

Similar efficacy between intra- and periarticular injections for acromioclavicular joint

AAOS 2016: Femoral nerve block vs. periarticular injection in total knee arthroplasty

Periarticular analgesic cocktail injection effective in reducing pain after TKA

AAOS2017: Analgesic efficacy of motor-sparing block vs. periarticular injection in TKA

Steroid addition to multimodal cocktail periarticular injection safe and effective in TKA

Lumbar plexus block vs periarticular infiltration with ropivacaine or liposomal bupivacaine in THA

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