Knee OA - The therapeutic trajectory of corticosteroids and hyaluronic acid

Arthritis Rheum. 2009 Dec 15;61(12):1704-11

Hyaluronic acid versus corticosteroid in the treatment of knee osteoarthritis

Intra-articular hyaluronic acid provides longer pain relief as compared to corticosteroid

Exp Ther Med. 2015 Feb;9(2):493-500.

Differences in hyaluronic acid characteristics influence outcomes in knee OA patients

Am J Sports Med. 2016 Aug;44(8):2158-65

Efficacy of hyaluronic acid vs placebo for pain relief in knee OA; meta-analysis of RCTs

J Fam Pract. 2005 Sep;54(9):758-67

Hyaluronic acid vs corticoid injections for osteoarthritis of the first carpometacarpal

Joint Bone Spine. 2015 Mar;82(2):116-21.

Small effect of hyaluronic acid for pain relief in treatment of knee osteoarthrits

JAMA. 2003 Dec 17;290(23):3115-21

Analysis of efficacy of different hyaluronic acid products in treatment of knee OA

BioDrugs. 2012 Aug 1;26(4):257-68

Limited efficacy of intra-articular hyaluronic acid in treatment of knee OA

CMAJ. 2005 Apr 12;172(8):1039-43

Improvement of condition with hyaluronic acid injection for ankle OA

Arch Phys Med Rehabil. 2013 May;94(5):951-60. doi: 10.1016/j.apmr.2012.10.030. Epub 2012 Nov 10

Hyaluronic acid and exercise therapy, in combination or as monotherapy, for knee OA

Knee Surg Sports Traumatol Arthrosc. 2016 May;24(5):1686-94

IA versus oral hyaluronic acid in the treatment of patients with KL grade I-II knee osteoarthritis

Musculoskelet Surg. 2017 Apr;101(1):45-49. doi: 10.1007/s12306-016-0428-x

AAOS: Reporting of hyaluronic acid efficacy in knee OA may be influenced by industry

Hyaluronic acid more clinically effective compared to betamethasone for knee OA

Open Access Rheumatology: Research and Reviews 2015:7 9–18

Consistent pain improvement from 4-24 weeks with hyaluronic acid in knee osteoarthritis

Osteoarthritis Cartilage. 2011 Jun;19(6):611-9

OARSI 2016: Similar pain relief between combined hyaluronic acid(HA)/mannitol and high MW

Hyaluronic acid injections reduce IL-1B and severity of knee OA after 5 weeks

Pak J Pharm Sci. 2015 Jan;28(1 Suppl):407-10.

Comparison of combined hyaluronic acid (HA) and corticosteroid vs. HA alone injection for knee OA

Exp Ther Med. 2018 Sep;16(3):1928-1934. doi: 10.3892/etm.2018.6371

Hyaluronic acid did not yield superior outcomes for hip osteoarthritis

Arthritis Rheum. 2009 Mar;60(3):824-30

HA more effective than placebo in knee OA, no difference between 3 and 6 injections of HA

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