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Celecoxib and aceclofenac reduce COX-2 and mPEGS-1 expression in osteoarthritic patients

Osteoarthritis Cartilage. 2008 Dec;16(12):1484-93. Epub 2008 Jun 10

RCT General Orthopaedics Osteoarthritis Lower Extremity Knee Arthritis Cartilage Celecoxib Aceclofenac - Hide

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Perioperative administration of cyclooxygenase-2 inhibitors reduces pain in TKA patients

J Arthroplasty. 2013 Feb;28(2):207-213.e2. doi: 10.1016/j.arth.2012.04.008. Epub 2012 Jun 7

Meta-analysis Arthroplasty Lower Extremity Knee Pain Analgesia Opioid TKA - Hide

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Preliminary evidence of increased re-tear rate with COX-2 inhibitors after rotator cuff repair

Am J Sports Med. 2018 Mar;46(3):679-686

RCT Shoulder & Elbow Upper Extremity Muscle Rotator Cuff Pain Tear Pfizer Ibuprofen Celecoxib Tramadol Oxycodone Arthroscopic - Hide

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5-hydroxytryptamine receptor inhibitor is safe and effective for treatment of lumbar disc

J Neurosurg Spine. 2005 Apr;2(4):441-6

RCT Spine Discs Hernia Sciatica Lumbar Inflammation Herniation Diclofenac Receptor Inhibitor - Hide

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Celecoxib vs. diclofenac plus omeprazole for OA or RA treatment with lesser GI risk

Lancet. 2010 Jul 17;376(9736):173-9. Epub 2010 Jun 16

RCT Osteoarthritis Arthritis Pfizer Celecoxib Diclofenac Omeprazole - Hide

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THR: Celecoxib more effective than ibuprofen in prevention of heterotopic bone formation

J Bone Joint Surg Br. 2007 Feb;89(2):155-9.

RCT Arthroplasty Osteoarthritis Lower Extremity Hip Arthritis Ibuprofen Celecoxib Inhibitor Prevention Replacement THR - Hide

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NSAIDs reduce pain in the short-term when used to treat patients with knee osteoarthritis

BMJ. 2004 Dec 4;329(7478):1317

Meta-analysis Osteoarthritis Lower Extremity Knee Arthritis Inflammation Pain Celecoxib Diclofenac Naproxen Rofecoxib Etodolac Lumiracoxib Meloxicam Valdecoxib Nabumetone Oxaprozin Flurbiprofen Tiaprofenic Acid Diflunisal Analgesic Inhibitor NSAID Nsaids Placebo - Hide

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Electro-acupuncture reduces arthralgia in cancer patients taking aromatase inhibitors

Eur J Cancer. 2014 Jan;50(2):267-76. doi: 10.1016/j.ejca.2013.09.022. Epub 2013 Oct 24

RCT Tumour Breast Metastasis Women Pain Electro-Acupuncture Inhibitor - Hide

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Celecoxib decreases post-operative pain and lowers morphine consumption after TKR

Acta Orthop. 2007 Oct;78(5):661-7

RCT Arthroplasty Lower Extremity Knee Pain Celecoxib Blood Loss Placebo Preoperatively Replacement TKR - Hide

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The short-term effectiveness of pharmacotherapeutic interventions for knee osteoarthritis

Eur J Pain. 2007 Feb;11(2):125-38. Epub 2006 May 8.

Meta-analysis Osteoarthritis Lower Extremity Knee Arthritis Pain Paracetamol Chondroitin Sulphate Glucosamine Sulphate Inhibitor Opioid Oral NSAID Placebo Steroid Injections - Hide

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Effect of tranexamic acid and indirect factor Xa inhibitor on blood loss and DVT after TKA

Knee Surg Sports Traumatol Arthrosc. 2013 Nov;21(11):2611-7

RCT Arthroplasty Lower Extremity Knee GlaxoSmithKline Fondaparinux Tranexamic Acid Blood Loss Factor Implantation Inhibitor TKA Surgery Tourniquet Release - Hide

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Efficacy of various celecoxib doses versus naproxen and placebo in knee osteoarthritis treatment

Mayo Clin Proc. 1999 Nov;74(11):1095-105

RCT Osteoarthritis Lower Extremity Knee Arthritis Celecoxib Naproxen Placebo - Hide

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Golimumab treatment provides superior treatment of rheumatoid arthritis

Lancet. 2009 Jul 18;374(9685):210-21. Epub 2009 Jun 26

RCT General Orthopaedics Tumour Arthritis Necrosis Golimumab Injection Inhibitor Placebo - Hide

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OARSI 2016: Potential benefit of Wnt inhibitor, SM04690, in moderate to severe knee OA

RCT Osteoarthritis Lower Extremity Knee Arthritis Injection Inhibitor Placebo - Hide

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Cindunistat not effective in slowing the progression of knee osteoarthritis

Ann Rheum Dis. 2013 Feb;72(2):187-95. doi: 10.1136/annrheumdis-2012-202239. Epub 2012 Nov 10

RCT Osteoarthritis Lower Extremity Knee Arthritis Pfizer Cindunistat Inhibitor Placebo - Hide

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TKA analgesic: Periarticular injection with steroids superior to those without steroids

Chin Med J (Engl). 2013 Oct;126(20):3851-5

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Celecoxib Morphine Analgesic Multimodal Periarticular Injection Standard Medial Parapatellar Arthrotomy Steroid TKA - Hide

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Parecoxib use reduces pain and opioid consumption post-total knee arthroplasty compared to placebo

Int J Surg. 2018 Nov;59:67-74

Meta-analysis Arthroplasty Lower Extremity Knee Pain Parecoxib Analgesia Analgesic Control Current Inhibitor Opioid - Hide

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Edoxaban has similar efficacy to enoxaparin for thromboprophylaxis after THA

J Arthroplasty. 2014 Dec;29(12):2439-46.

RCT Arthroplasty Lower Extremity Hip Daiichi Sankyo Sankyo Edoxaban Enoxaparin Sodium Thromboprophylaxis - Hide

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Etoricoxib and diclofenac similar for blood loss and GI distress rates after THA

Curr Med Res Opin. 2016 Jan;32(1):37-47.

RCT Arthroplasty Osteoarthritis Lower Extremity Hip Arthritis Medtronic Novartis Etoricoxib Blood Loss Diclofenac Sodium THA - Hide

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Apixiban more effective than enoxaparin for prevention of postoperative thromboembolism

Lancet. 2010 Mar 6;375(9717):807-15.

RCT Arthroplasty Thromboembolism Lower Extremity Knee Bristol-Myers Squibb Pfizer Apixaban Oral Prevention Replacement Subcutaneous Enoxaparin - Hide

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Celecoxib and aceclofenac reduce COX-2 and mPEGS-1 expression in osteoarthritic patients

Perioperative administration of cyclooxygenase-2 inhibitors reduces pain in TKA patients

Preliminary evidence of increased re-tear rate with COX-2 inhibitors after rotator cuff repair

5-hydroxytryptamine receptor inhibitor is safe and effective for treatment of lumbar disc

Celecoxib vs. diclofenac plus omeprazole for OA or RA treatment with lesser GI risk

THR: Celecoxib more effective than ibuprofen in prevention of heterotopic bone formation

NSAIDs reduce pain in the short-term when used to treat patients with knee osteoarthritis

Electro-acupuncture reduces arthralgia in cancer patients taking aromatase inhibitors

Celecoxib decreases post-operative pain and lowers morphine consumption after TKR

The short-term effectiveness of pharmacotherapeutic interventions for knee osteoarthritis

Effect of tranexamic acid and indirect factor Xa inhibitor on blood loss and DVT after TKA

Efficacy of various celecoxib doses versus naproxen and placebo in knee osteoarthritis treatment

Golimumab treatment provides superior treatment of rheumatoid arthritis

OARSI 2016: Potential benefit of Wnt inhibitor, SM04690, in moderate to severe knee OA

Cindunistat not effective in slowing the progression of knee osteoarthritis

TKA analgesic: Periarticular injection with steroids superior to those without steroids

Parecoxib use reduces pain and opioid consumption post-total knee arthroplasty compared to placebo

Edoxaban has similar efficacy to enoxaparin for thromboprophylaxis after THA

Etoricoxib and diclofenac similar for blood loss and GI distress rates after THA

Apixiban more effective than enoxaparin for prevention of postoperative thromboembolism

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