Thomas Frydendal

PT, MSc, PhD

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Mohit Bhandari

FRCSC, PhD

Distinguished University Professor, Chair of Surgery, McMaster University

Marc Swiontkowski

MD, FAOA

Professor, University of Minnesota

This episode centers on a rare and methodologically ambitious surgical-versus-rehabilitation RCT in severe hip osteoarthritis, featuring Danish physiotherapist-researcher Thomas Frydendal. The discussion frames the long-standing clinical tension between “exercise can solve it” and “arthroplasty is definitive,” and positions the trial as a pragmatic tool for shared decision-making rather than professional turf. In 109 patients with severe radiographic OA and marked pain/disability, total hip replacement produced a clinically meaningful advantage over a 6-month resistance-training program on the Oxford Hip Score at the 6-month primary endpoint (≈11.4 points on a 0–48 scale, exceeding a ~5-point threshold for clinical relevance), with planned longer follow-up and anticipated crossover acknowledged as a design challenge. Beyond results, Frydendal details the human cost of running a decade-long trial during a PhD, and the professional upside—credibility, network expansion, and academic recognition—while reinforcing a persistent, patient-question–driven research ethos. The conversation closes by linking this work to his next multicenter trial testing whether supervised physiotherapy adds benefit beyond patient education alone in milder OA.