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RCT
ACE Report #9896
Ace Report Cover Osteoarthritis

IA glucocorticioid not associated with decrease in synovitis when compared to IA saline for knee OA


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

The effects of intra-articular glucocorticoids and exercise on pain and synovitis assessed on static and dynamic magnetic resonance imaging in knee osteoarthritis: exploratory outcomes from a randomized controlled trial

Osteoarthritis Cartilage. 2017 Apr;25(4):481-491

Contributing Authors: M Boesen H Bliddal M Henriksen L Klokker C Bartholdy E Bandak K Ellegaard RG Riis BB Hansen

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Synopsis

100 patients with a clinical diagnosis of knee osteoarthritis and symptomatic pain on walking were included in this study to assess the effect of corticosteroid injections on synovitis and how this may mediate pain reduction. Patients were randomized to undergo either a single methylprednisolone or saline injection. As part of the treatment, all patients participated in an individualized exercise ...

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