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RCT
ACE Report #9857
Ace Report Cover Osteoarthritis

Comparison of efficacy and safety of two single injection hyaluronic acid preparations for knee OA


Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Comparison of Single Intra-Articular Injection of Novel Hyaluronan (HYA-JOINT Plus) with Synvisc-One for Knee Osteoarthritis: A Randomized, Controlled, Double-Blind Trial of Efficacy and Safety

J Bone Joint Surg Am. 2017 Mar 15;99(6):462-471

Contributing Authors: SF Sun CW Hsu HS Lin IH Liou YH Chen CL Hung

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Synopsis

132 patients with mild-to-moderate, symptomatic knee osteoarthritis were randomized to a single injection of either HYA-JOINT Plus (SciVision Biotech) or Synvisc-One (Sanofi-Aventis). Patients were assessed over a 6-month follow-up for patient-reported outcome measures, functional performance measures, patient satisfaction, and rate of adverse events. Pain assessed using a visual analog scale was ...

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