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RCT
ACE Report #9816
Ace Report Cover Osteoarthritis

Glucosamine and chondroitin combined therapy and monotherapy vs celecoxib and placebo for knee OA


Study Type:Therapy
OE Level Evidence:N/A
Journal Level of Evidence:N/A

Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis

N Engl J Med. 2006 Feb 23;354(8):795-808

Contributing Authors: NE Lane TJ Schnitzer RW Moskowitz CO Bingham III CV Oddis KD Brandt HR Schumacher LW Moreland DO Clegg DJ Reda CL Harris MA Klein JR O'Dell MM Hooper JD Bradley MH Weisman CG Jackson JJ Cush F Wolfe JA Molitor DE Yocum DE Furst AD Sawitzke H Shi HJ Williams

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Synopsis

1583 patients with symptomatic knee osteoarthritis were randomized to either glucosamine monotherapy, chondroitin monotherapy, combined glucosamine and chondroitin therapy, celecoxib 200mg daily, or placebo. Patients were assessed over 24 weeks of treatment. In the primary analysis, only the celecoxib group demonstrated a significantly higher rate of patients attaining the primary efficacy endpoin...

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