Glucosamine and chondroitin combined therapy and monotherapy vs celecoxib and placebo for knee OA
Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritisN Engl J Med. 2006 Feb 23;354(8):795-808
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1583 patients with symptomatic knee osteoarthritis were randomized to either glucosamine monotherapy, chondroitin monotherapy, combined glucosamine and chondroitin therapy, celecoxib 200mg daily, or placebo. Patients were assessed over 24 weeks of treatment. In the primary analysis, only the celecoxib group demonstrated a significantly higher rate of patients attaining the primary efficacy endpoin...
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