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Meta-analysis
ACE Report #9806
Ace Report Cover Osteoarthritis

Network meta-analysis of NSAIDs vs. diacerein vs. glucosamine in knee osteoarthritis treatment


Study Type:Meta-analysis/Systematic Review
OE Level Evidence:N/A
Journal Level of Evidence:N/A

Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: a systematic review and network meta-analysis

Eur J Med Res. 2015 Mar 13;20:24

Contributing Authors: P Woratanarat J Kongtharvonskul M McEvoy J Attia A Thakkinstian T Anothaisintawee

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Synopsis

31 randomized controlled trials were included in this network meta-analysis comparing the efficacies of diacerein, glucosamine, non-steroid anti-inflammatory drug therapy, and placebo in patients with knee osteoarthritis. Relative to placebo, indirect comparisons demonstrated each of diacerein, glucosamine, and NSAID therapy had significantly greater effects on pain reduction, though the relative ...

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