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Tanezumab in Japanese patients with moderate to severe osteoarthritis of the knee
August 2013
Tanezumab in Japanese patients with moderate to severe osteoarthritis of the knee
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A
Preliminary assessment of the safety and efficacy of tanezumab in Japanese patients with moderate to severe osteoarthritis of the knee: A randomized, double-blind, dose-escalation, placebo-controlled study
Osteoarthritis Cartilage; 2011;19(12):1405-1412Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
83 Japanese patients with moderate to severe osteoarthritis of the knee were randomized to receive either tanezumab 10, 25, 50, 100 or 200 mg/kg or a placebo. The results from 120 day follow-up indicated that stronger doses of tanezumab result in significantly better pain relief in comparison to baseline measurements. However, the results from the study also indicated that adverse events occurred ...
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