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Efficacy of dexmedetomidine vs. placebo for postoperative opioid use after TKA
August 2016
Efficacy of dexmedetomidine vs. placebo for postoperative opioid use after TKA
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A
Dexmedetomidine during total knee arthroplasty performed under spinal anesthesia decreases opioid use: a randomized-controlled trial
Can J Anaesth. 2016 May;63(5):569-576.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
40 patients scheduled for primary unilateral TKA were randomized to undergo the procedure with spinal anaesthesia with or without a loading dose of intravenous dexmedetomidine. The purpose of this study was to determine if dexmedetomidine was associated with significantly decreased postoperative consumption of morphine when compared to placebo up to 24 hours postoperatively. Secondary outcomes of ...
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