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Volume:5 Issue:5 Number:69 ISSN#:2563-5476
Author Verified
ACE Report #8814
Ace Report Cover Spine

The use of OP-1 (BMP-7) is not recommended for instrumented single-level lumbar fusion

How to Cite

OrthoEvidence. The use of OP-1 (BMP-7) is not recommended for instrumented single-level lumbar fusion. ACE Report. 2016;5(5):69. Available from: https://myorthoevidene.com/AceReport/Report/8814

Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

OP-1 Compared with Iliac Crest Autograft in Instrumented Posterolateral Fusion: A Randomized, Multicenter Non-Inferiority Trial

J Bone Joint Surg Am. 2016 Mar 16;98(6):441-8

Contributing Authors: D Delawi W Jacobs JL van Susante L Rillardon D Prestamburgo N Specchia E Gay N Verschoor C Garcia-Fernandez E Guerado H Quarles van Ufford MC Kruyt WJ Dhert FC Oner

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119 patients scheduled for instrumented single-level posterolateral lumbar fusion were randomized to a graft source of either osteogenic protein-1 (OP-1; Stryker) or autologous iliac crest bone (ICBG). The purpose of this study was to evaluate if OP-1 was non-inferior to ICBG based on an overall success endpoint which was defined as successful fusion, a relative improvement on the Oswestry Disabil...

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