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RCT
ACE Report #8340
Ace Report Cover Osteoarthritis

Efficacy of hyaluronic acid for pain reduction in knee OA versus control arthrocentesis


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Clinical effects of intraarticular injection of high molecular weight hyaluronan (Orthovisc) in osteoarthritis of the knee: a randomized, controlled, multicenter trial

J Rheumatol. 2005 Oct;32(10):1928-36

Contributing Authors: D Neustadt J Caldwell M Bell J Wade J Gimbel

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Synopsis

372 patients with Kellgren-Lawrence grade I-III knee osteoarthritis (OA) were randomized to either four intra-articular injections of high-molecular-weight (HMW) hyaluronic acid (HA), three intra-articular injections of HMW HA and one control arthrocentesis, or four sessions of control arthrocentesis. The primary outcome was the percentage of patients demonstrating a minimum 20% relative reduction...

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