OTA 2015: PTH bone-graft substitute vs. cancellous autograft for tibial plateau fractures
A Novel PTH-Based Bone Graft Substitute Demonstrates Noninferiority to Autograft in a Large Phase IIb Study of Tibial Plateau Fractures
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183 patients with a tibial plateau fracture were randomized to receive either a modified form of parathyroid hormone (PTH) in fibrin with hydroxapatite/tricalcium phosphate (HA/TCP) granules, or cancellous bone autograft following open reduction and internal fixation. Patients randomized to receive the bone graft substitute were treated with either a low-concentration (0.4mg/mL) or high-concentrat...
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