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ACE Report #8226
Ace Report Cover Trauma

OTA 2015: PTH bone-graft substitute vs. cancellous autograft for tibial plateau fractures

Study Type:Randomized Trial
OE Level Evidence:N/A
Journal Level of Evidence:N/A

A Novel PTH-Based Bone Graft Substitute Demonstrates Noninferiority to Autograft in a Large Phase IIb Study of Tibial Plateau Fractures

Contributing Authors: T Lyon FB Garcia A Bohatyrewciz V Casa de Pantoja Z Detre K Dresing F Dubrana P Giannoudis A Gorecki T Gunther W Harries PM Hax C Krettek K Kwiatkowski ML Vence Z Magyari H Mathevon P Messmer K Mohanty E Montanez A Pace A Patel Piltz

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This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.


183 patients with a tibial plateau fracture were randomized to receive either a modified form of parathyroid hormone (PTH) in fibrin with hydroxapatite/tricalcium phosphate (HA/TCP) granules, or cancellous bone autograft following open reduction and internal fixation. Patients randomized to receive the bone graft substitute were treated with either a low-concentration (0.4mg/mL) or high-concentrat...

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