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ACE Report #8177
Ace Report Cover Osteoarthritis

Efficacy of hyaluronate vs placebo injection for pain reduction in symptomatic knee OA

Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Clinical trial of intra-articular injection of sodium hyaluronate in patients with osteoarthritis of the knee

Curr Med Res Opin. 1988;11(4):205-13.

Contributing Authors: AS Dixon RK Jacoby H Berry EB Hamilton

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63 patients with knee osteoarthritis were randomly assigned to receive either sodium hyaluronate (HA) or placebo intra-articular injections. The purpose of this study was to compare the efficacy of hyaluronate injections with placebo injections for reducing pain associated with knee OA. Both pain at rest and pain on movement were measured using a 100mm visual analogue scale (VAS) over 23 week foll...

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