Reduced pain and disability over 26 weeks in patients treated with IA hyaluronan vs. sham

Study Type:Randomized Trial

OE Level Evidence:2

Journal Level of Evidence:N/A

Viscosupplementation with hylan G-F 20: a 26-week controlled trial of efficacy and safety in the osteoarthritic knee

Clin Ther. 1998 May-Jun;20(3):410-23

Contributing Authors: M Wobig A Dickhut R Maier G Vetter

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Synopsis

110 patients (117 knees) with knee osteoarthritis were randomized to three weekly intra-articular injections of either hyaluronan (HA) (Hylan G-F 20) or saline. The purpose of this study was to evaluate and compare outcomes of pain and loss of activity between groups. Visual analog scales were used in the evaluation of patients over 26 weeks following the first injection. Results demonstrated sign...