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ACE Report #8166
Ace Report Cover Osteoarthritis

High/low molecular weight HA injection vs. placebo in knee OA

Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

A prospective randomised controlled clinical trial comparing the efficacy of different molecular weight hyaluronan solutions in the treatment of knee osteoarthritis

Rheumatol Int. 2006 Feb;26(4):325-30

Contributing Authors: N Kotevoglu PC Iyibozkurt O Hiz H Toktas B Kuran

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78 patients with a confirmed diagnosis of knee osteoarthritis were randomized to receive intra-articular injections of either a hyaluronan product (Orthovisc), a high-molecular-weight hyaluronan product (Synvisc), or placebo, weekly. The purpose of the study was to compare the efficacy of these different formulations of hyaluronic acid. The results of this study indicated improvements in pain, fun...

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